Multiple plex quantitative proteomic analysis of neuroserpin-deficient and control mice, for the murine brain, retain and optic nerve
Ontology highlight
ABSTRACT: Neural regeneration and neuroprotection represent promising therapeutic approaches for neurodegenerative disorders like Alzheimer's disease (AD) or glaucoma. However, the molecular mechanisms that lead to neuroprotection are not clearly understood. One of the promising candidates to revive physiological function is neuroserpin (Serpini1), a serine protease inhibitor expressed by neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury. Abnormal function of this protein has been implicated in stroke, glaucoma, AD and FENIB. Here we report proteome changes by neuroserpin modulation in brains, retinas, and optic nerves from 12-month C57BL6/J neuroserpin deficient mice (NeuS-/-).
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Shahab Mirshahvaladi
LAB HEAD: Vivek Gupta
PROVIDER: PXD046873 | Pride | 2023-11-12
REPOSITORIES: Pride
ACCESS DATA