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Leishmania Ribosomal Protein (RP) paralogous genes compensate each other’s expression maintaining protein native levels

ABSTRACT: We investigated the potential compensatory mechanism and possibility of noncanonical function of ribosomal proteins encoded by duplicated genes in Leishmania major.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Leishmania Major

DISEASE(S): Leishmaniasis

SUBMITTER: Lissur Orsine

LAB HEAD: Angela Kaysel

PROVIDER: PXD047334 | Pride | 2024-06-03

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	27777-27794_KCruzA_LMajorLV39_20221213.sf3	Other
	Ingel27777_KayselCruzA_01.raw	Raw
	Ingel27777_KayselCruzA_01_F006845.mzid.gz	Mzid
	Ingel27777_KayselCruzA_01_F006845.mzid_Ingel27777_KayselCruzA_01_F006845.MGF	Mzid
	Ingel27778_KayselCruzA_02.raw	Raw

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Publications

Leishmania Ribosomal Protein (RP) paralogous genes compensate each other's expression maintaining protein native levels.

Borges Francisca S FS Quilles José C JC Lorenzon Lucas B LB Espada Caroline R CR Freitas-Castro Felipe F Defina Tânia P A TPA Holetz Fabíola B FB Cruz Angela K AK

PloS one 20240516 5

In the protozoan parasite Leishmania, most genes encoding for ribosomal proteins (RPs) are present as two or more copies in the genome. However, their untranslated regions (UTRs) are predominantly divergent and might be associated with a distinct regulation of the expression of paralogous genes. Herein, we investigated the expression profiles of two RPs (S16 and L13a) encoded by duplicated genes in Leishmania major. The genes encoding for the S16 protein possess identical coding sequences (CDSs) ...[more]

PMID: 38753846

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