Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Podospora Anserina
TISSUE(S): Cell Culture
SUBMITTER: Jana Key
LAB HEAD: Prof. Georg Auburger
PROVIDER: PXD048640 | Pride | 2024-06-22
REPOSITORIES: Pride
Action | DRS | |||
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Data_analysis.xlsx | Xlsx | |||
Kurzgele.tif | Other | |||
P18_078_Podospora_Sample02_01.raw | Raw | |||
P18_078_Podospora_Sample02_02.raw | Raw | |||
P18_078_Podospora_Sample02_03.raw | Raw |
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Biomolecules 20240219 2
The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia. In the filamentous fungus <i>Podospora anserina</i>, CLPP loss leads to longevity. CLPP substrates are selected by CLPX, an AAA+ unfoldase. CLPX is known to target delta-aminolevulinic acid synthase (ALAS) to promote pyridoxal phosphate (PLP) binding. CLPX may also influence cofactor a ...[more]