Dataset Information

Sex Differences in Response to Glutathione Precursors in the Aging Heart

ABSTRACT: Diastolic dysfunction in the aged population is multifactorial. Common features of the aging heart are dysregulated metabolism, elevated oxidative stress, inflammation and fibrosis, where each of these conditions can linked together and further promote the altered phenotype. It becomes increasingly apparent that aged male and female hearts are phenotypically different and these basic differences dictate their responses to treatments such as a response to antioxidants. We used Glycine and N-Acetyl-Cysteine (GlyNAC, precursors of glutathione)- supplemented diet to monitor its effect on cardiac function and exercise performance. We found that this pharmacological intervention was beneficial for male but not female aged mice and the small but significant changes were observed not only on cardiac functions but also on molecular levels where fatty acid metabolism was improved and cardiac matrix stiffness was reduced.

INSTRUMENT(S): Orbitrap Eclipse, Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Alexander Saltzman

LAB HEAD: Katarzyna Cieslik

PROVIDER: PXD048895 | Pride | 2024-11-05

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	52355_1_7_labelTMT_e2g_QUAL.tsv	Tabular
	52355_1_7_labelTMT_e2g_QUANT.tsv	Tabular
	52355_1_7_labelTMT_psms_QUAL.tsv	Tabular
	52355_1_7_labelTMT_psms_QUANT.tsv	Tabular
	52355_1_ECL_992_mm_heart_TMT16_200ng_F01.mzML	Mzml

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Publications

Sex Differences in Response to Diet Enriched with Glutathione Precursors in the Aging Heart.

Angelini Aude A Garcia Marquez Grecia G Malovannaya Anna A Fiorotto Marta L ML Saltzman Alexander A Jain Antrix A Trial Jo Ann JA Taffet George E GE Cieslik Katarzyna A KA

The journals of gerontology. Series A, Biological sciences and medical sciences 20241104

Common features of the aging heart are dysregulated metabolism, inflammation, and fibrosis. Elevated oxidative stress is another hallmark of cardiac aging that can exacerbate each of these conditions. We hypothesize that by increasing natural antioxidant levels (glutathione), we will improve cardiac function. Twenty-one-month-old mice were fed Glycine and N-Acetyl Cysteine (GlyNAC) (glutathione precursors)-supplemented or control diets for 12 weeks. Heart function was monitored longitudinally, a ...[more]

PMID: 39492659

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