Proteomics

Dataset Information

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Secretome and phosphoproteome analysis of THP-1 and KOPN-8 cells treated with Insulin-like growth factor 2.


ABSTRACT: We describe the secretome and phosphoproteome of human leukemia cell lines, THP-1 and KOPN-8, treated with Insulin-like growth factor 2 (IGF2) using data-independent acquisition mass spectrometry analysis.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Sudip Ghosh  

LAB HEAD: Dr Jenny Hansson

PROVIDER: PXD049016 | Pride | 2024-04-02

REPOSITORIES: Pride

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Publications

A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia.

Jassinskaja Maria M   Ghosh Sudip S   Watral Joanna J   Davoudi Mina M   Claesson Stern Melina M   Daher Ugarit U   Eldeeb Mohamed M   Zhang Qinyu Q   Bryder David D   Hansson Jenny J  

Leukemia 20240330 5


Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, highlighting a complex interplay of intra- and extracellular factors in determining disease subtype. W  ...[more]

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