Proteomics

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Evaluation of the impact of the dietary inclusion of salty and sugary former food products on the liver and plasma profile of pigs through OMICS approaches


ABSTRACT: The research on alternative and sustainable feed ingredients is a challenge to reduce feed-food competition between humans and monogastrics, in particular pigs. Former food products (FFPs) drop out from the industrial production of food such as pasta, bread, snacks, and chips. They have a high nutritional and energetic value and represent an alternative and sustainable feed ingredient. The aim of this study was to apply omics tools to assess the impact of the dietary inclusion of FFPs in pigs’ diet. For the in vivo trial, thirty-six Swiss Large White male castrated pigs were randomly assigned to three dietary groups: control (CTR), 30% replacement of CTR diet with salty FFPs (SA), 30% replacement of CTR diet with sugary FFPs (SU). The trial lasted from the start of the growing phase (22.4 ± 1.7 kg) until slaughtering phase (110 ± 3 kg). After slaughtering, blood and liver tissue samples were collected and processed according to the omics approaches used. The number of differentially regulated proteins in each comparison matrix (SA/SU vs. CTR) indicated a marginal impact on liver function, as measured by proteomics on tissue samples. The peptidomics investigation on plasma samples showed low variability between the peptidome of the three dietary groups and identified three possible bioactive peptides associated with anti-hypertension in the SA dietary group. To conclude, the safety and the limited impact of the SA and SU diets on liver proteome and plasma peptidome strengthened the idea of recycling FFPs as feed ingredients to make pig production more sustainable.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Liver

SUBMITTER: Alessandra Altomare  

LAB HEAD: Alessandra Altomare

PROVIDER: PXD049972 | Pride | 2024-10-17

REPOSITORIES: Pride

Dataset's files

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Action DRS
23P31-CA-01.msf Msf
23P31-CA-01.raw Raw
23P31-CA-02.msf Msf
23P31-CA-02.raw Raw
23P31-CA-03.msf Msf
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Publications

Preliminary investigation on the impact of salty and sugary former foods on pig liver and plasma profiles using OMICS approaches.

Manoni Michele M   Altomare Alessandra A   Nonnis Simona S   Ferrario Giulio G   Mazzoleni Sharon S   Tretola Marco M   Bee Giuseppe G   Tedeschi Gabriella G   Aldini Giancarlo G   Pinotti Luciano L  

Scientific reports 20240821 1


Replacing cereals with food leftovers could reduce feed-food competition and keep nutrients and energy in the food chain. Former food products (FFPs) are industrial food leftovers no more intended for human but still suitable as alternative and sustainable feedstuffs for monogastric. In this study, omics approaches were applied to evaluate the impact of dietary FFPs on pig liver proteome and plasma peptidome. Thirty-six Swiss Large White male castrated pigs were randomly assigned to three dietar  ...[more]

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