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Mouse cortex quantitative LC-MS/MS analysis

ABSTRACT: Quantitative mass spectrometry (MS) comparing E14.5 WT and Kctd10-cKO cortical samples was performed to identify the functional consequence of KCTD10 loss on protein abundance. A total of 3,442 differentially expressed proteins (DEPs) were identified using three or more biological replicates.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: 玲袁

LAB HEAD: Ling Yuan

PROVIDER: PXD050077 | Pride | 2024-06-23

REPOSITORIES: Pride

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			Action	DRS
	XA02405LQ_CKO_1.raw	Raw
	XA02405LQ_CKO_2.raw	Raw
	XA02405LQ_CKO_3.raw	Raw
	XA02405LQ_CKO_4.raw	Raw
	XA02405LQ_WT_1.raw	Raw

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Publications

KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.

Cheng Jianbo J Wang Zhen Z Tang Manpei M Zhang Wen W Li Guozhong G Tan Senwei S Mu Chenjun C Hu Mengyuan M Zhang Dan D Jia Xiangbin X Wen Yangxuan Y Guo Hui H Xu Dan D Liu Liang L Li Jiada J Xia Kun K Li Faxiang F Duan Ranhui R Xu Zhiheng Z Yuan Ling L

Proceedings of the National Academy of Sciences of the United States of America 20240315 12

KCTD10 belongs to the KCTD (potassiumchannel tetramerization domain) family, many members of which are associated with neuropsychiatric disorders. However, the biological function underlying the association with brain disorders remains to be explored. Here, we reveal that Kctd10 is highly expressed in neuronal progenitors and layer V neurons throughout brain development. <i>Kctd10</i> deficiency triggers abnormal proliferation and differentiation of neuronal progenitors, reduced deep-layer (espe ...[more]

PMID: 38489388

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