No evidence for the presence and control of tumor growth by stress granules in Kras mutant cancers

ABSTRACT: Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation. Consequently, the aberrant assembly or disassembly of these granules has pathological implications in neurodegeneration and cancer. In the latter situation, and particularly in the presence of mutations in the KRAS oncogene, in vivo studies have led to the idea that SG play an important role within cancer cells to increase their resistance to stress. Hence, SG have recently been considered as a promising new target for cancer therapy. In the present study, starting from an interest in G3BP1, a protein essential for the formation of SG, we came to look for the presence of SG during tumorigenesis. Through various experiments which combine in vitro, in vivo, and in silico approaches, performed both on mouse models and human samples and data, we reached the conclusion that SG are not present in KRAS-driven tumors, and therefore could not be considered as a valid therapeutic target for cancer treatment

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreas

DISEASE(S): Pancreatic Cancer

SUBMITTER: Didier Vertommen  

LAB HEAD: Dr Patrick Jacquemin

PROVIDER: PXD053882 | Pride | 2024-09-24

REPOSITORIES: pride