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Parallel genetic excisions of the cardiac troponin I N-terminal extension in tachycardic mammals

ABSTRACT: A study of cardiac troponin I evolution in mammals with high heart rates, including shrews, moles, and bats. With genomic, mRNA and protein level analyses we showed repeated loss of the N-terminal extension. Here, liquid chromatography with tandem mass spectrometry was used to verify cardiac troponin I (TNNI3) protein identity in ∼22 kDa bands from Pyrenean desman (Galemys pyrenaicus) and northern short-tailed shrew (Blarina brevicauda) hearts.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Galemys Pyrenaicus Blarina Brevicauda

TISSUE(S): Heart

SUBMITTER: William Joyce

LAB HEAD: Kevin L. Campbell

PROVIDER: PXD048600 | Pride | 2024-07-19

REPOSITORIES: Pride

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			Action	DRS
	Pyrenean_Desman_F006588.dat	Other
	S15930_Pyrenean_Desman_IP_231121.raw	Raw
	S15931_Short_Tailed_Shrew_IP_231121.raw	Raw
	Short_Tailed_Shrew_F006591.dat	Other
	checksum.txt	Txt

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