Proteomics

Dataset Information

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4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection


ABSTRACT: We applied a 4D dia-PASEF proteomic approach to investigate the salivary protein profile of individuals with early-to-acute SARS-CoV-2 Omicron infection. We combined proteomics and functional analyses with feature selection and ROC multivariate analysis to identify and assess salivary proteins for COVID-19 screening.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

DISEASE(S): Covid-19

SUBMITTER: Iasmim Lima  

LAB HEAD: Marcos Nogueira

PROVIDER: PXD054133 | Pride | 2025-01-18

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Results_DIA-NN.rar Other
Spectral_library.tsv.speclib Tabular
raw.rar Other
sample_info.txt Txt
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Publications

4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection.

de Lima Iasmim Lopes IL   Cataldi Thais Regiani TR   Brites Carlos C   Labate Mônica Teresa Veneziano MTV   Vaz Sara Nunes SN   Deminco Felice F   da Cunha Gustavo Santana GS   Labate Carlos Alberto CA   Eberlin Marcos Nogueira MN  

Journal of proteome research 20250113 2


Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections globally over the past two years. In this study, we investigated for the first time the host salivary response of COVID-19 patients infected with Omicron variants (BA.1, BA.2, and BA.4/5) by using an untargeted four-dimensional data-independent acquisition (4D-DIA)-based proteomics ap  ...[more]

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