Dataset Information

4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection

ABSTRACT: We applied a 4D dia-PASEF proteomic approach to investigate the salivary protein profile of individuals with early-to-acute SARS-CoV-2 Omicron infection. We combined proteomics and functional analyses with feature selection and ROC multivariate analysis to identify and assess salivary proteins for COVID-19 screening.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

DISEASE(S): Covid-19

SUBMITTER: Iasmim Lima

LAB HEAD: Marcos Nogueira

PROVIDER: PXD054133 | Pride | 2025-01-18

REPOSITORIES: pride

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4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection.

de Lima Iasmim Lopes IL Cataldi Thais Regiani TR Brites Carlos C Labate Mônica Teresa Veneziano MTV Vaz Sara Nunes SN Deminco Felice F da Cunha Gustavo Santana GS Labate Carlos Alberto CA Eberlin Marcos Nogueira MN

Journal of proteome research 20250113

Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections globally over the past two years. In this study, we investigated for the first time the host salivary response of COVID-19 patients infected with Omicron variants (BA.1, BA.2, and BA.4/5) by using an untargeted four-dimensional data-independent acquisition (4D-DIA)-based proteomics ap ...[more]

PMID: 39803891

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			Action	DRS
	Results_DIA-NN.rar	Other
	Spectral_library.tsv.speclib	Tabular
	raw.rar	Other
	sample_info.txt	Txt