Dataset Information
IMPRINTS-CETSA Alpelisib and Buparlisib in MCF-7 cells, 1h incubation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Marc-Antoine Gerault
LAB HEAD: Pär Nordlund
PROVIDER: PXD056196 | Pride | 2024-10-23
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MCF7_PI3K_1h_37_1.raw | Raw | |||
| MCF7_PI3K_1h_37_10.raw | Raw | |||
| MCF7_PI3K_1h_37_11.raw | Raw | |||
| MCF7_PI3K_1h_37_12.raw | Raw | |||
| MCF7_PI3K_1h_37_2.raw | Raw |
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Publications
Proteome-wide CETSA reveals diverse apoptosis-inducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery.
Cell reports 20241003 10
Cellular phenotypes of apoptosis, as well as the activation of apoptosis caspase cascades, are well described. However, sequences and locations of early biochemical effector events after apoptosis initiation are still only partly understood. Here, we use integrated modulation of protein interaction states-cellular thermal shift assay (IMPRINTS-CETSA) to dissect the cellular biochemistry of early stages of apoptosis at the systems level. Using 5 families of cancer drugs and a new CETSA-based meth ...[more]
