Proteomics

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Loss of GABAergic D-type motor neurons in young adult Caenorhabditis elegans after exposition with silica nanoparticles

ABSTRACT: Although C. elegans is commonly used to assess the neurotoxicity of environmental pollutants, studies that explore the intricate biology of its nervous system, particularly those addressing long term effects and aging in adult worms, are rare. These models offer significant advantages for understanding the full spectrum of neurobiological impacts. Here, we investigated the effects of silica nanomaterials on the GABAergic neural system in young to middle-aged nematodes. Results showed a novel degeneration pattern characterized by loss of anterior- and posteriormost GABAergic D-type motor neurons. Proteomics of 4-day-old C. elegans revealed significant alterations of protein abundance including the downregulation of proteins such as glutamate dehydrogenase (gdh-1), and glutamate oxaloacetate transaminase (got-1.2) which are essentially involved in GABA metabolic pathways.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Caenorhabditis Elegans

SUBMITTER: Gereon Poschmann  

LAB HEAD: Gereon Poschmann

PROVIDER: PXD056717 | Pride | 2025-03-25

REPOSITORIES: Pride

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Publications

Loss of γ-aminobutyric acid D-Type Motor Neurons in Young Adult <i>Caenorhabditis elegans</i> Following Exposition with Silica Nanoparticles.

Le Dang Tri DT   Pauls Stella S   Poschmann Gereon G   Stühler Kai K   von Mikecz Anna A  

Cells 20250127 3

Although <i>Caenorhabditis elegans</i> is commonly used to assess the neurotoxicity of environmental pollutants, studies that explore the intricate biology of its nervous system, particularly those addressing long-term effects and aging in adult worms, are rare. These models offer significant advantages for understanding the full spectrum of neurobiological impacts. Here, we investigated the effects of silica nanomaterials on the γ-aminobutyric acid (GABA) neural system in young to middle-aged n  ...[more]

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