Proteomics

Dataset Information

0

Discovery from in-depth molecular analyses of giant viruses: Haptophyte-infecting viruses change the genome condensing proteins of dinoflagellates


ABSTRACT: Giant viruses are extraordinary members of the virosphere due to their structural complexity and high diversity in gene content. Haptophytes are ecologically important primary producers in the ocean, and all known viruses that infect haptophytes are giant viruses. Our in-depth electron microscopic, phylogenomic and virion proteomic analyses of two haptophyte-infecting giant viruses, Haptolina ericina virus RF02 (HeV RF02) and Prymnesium kappa virus RF02 (PkV RF02), unravel their large capacity for host manipulation and arsenals that functions during the infection cycle from virus entry to release. The virus infection induces significant morphological changes of host cell that are manipulated to build a virus proliferation factory. Both viruses’ genomes encode a putative nucleoprotein (dinoflagellate/viral nucleoprotein; DVNP), which was also found in the virion proteome of PkV RF02. Phylogenetic analysis suggests that DVNPs are widespread in marine giant metaviromes. Furthermore, the analysis shows that the dinoflagellate homologues were possibly acquired from viruses of the order Imitervirales.

INSTRUMENT(S): Orbitrap Exploris 240

ORGANISM(S): Prymnesium Kappa Virus

SUBMITTER: Sergio Ciordia  

LAB HEAD: Carmen San Martín

PROVIDER: PXD060762 | Pride | 2025-02-21

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
20220511_53_1700_Banda8.raw Raw
20220511_GCondezo_1700_Banda8_Abundance.mzML Mzml
20220511_GCondezo_1700_Banda8_Abundance.mzid Mzid
SOtaegi_PROT-2017.mzML Mzml
SOtaegi_PROT-2017.mzid Mzid
Items per page:
1 - 5 of 6

Similar Datasets

2018-10-16 | E-MTAB-6614 | biostudies-arrayexpress
2016-09-06 | E-GEOD-81392 | biostudies-arrayexpress
2016-09-05 | E-GEOD-81391 | biostudies-arrayexpress
2016-09-06 | E-GEOD-81393 | biostudies-arrayexpress
2024-07-15 | GSE249241 | GEO
2016-09-28 | GSE77911 | GEO
2014-05-22 | PXD000993 | Pride
2020-08-06 | PXD019637 | Pride
2011-01-01 | E-GEOD-21736 | biostudies-arrayexpress
2024-07-25 | PXD040889 | Pride