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Comparing microbiome difference between wild type and Nlrp12-deficient mice

ABSTRACT: 16s rRNA sequencing of fecal DNA from wild type B6 mice and Nlrp12-deficient mice

PROVIDER: PRJEB18678 | ENA |

REPOSITORIES: ENA

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The Nlrp12 inflammasome negatively regulates NOD2-mediated adjuvanticity, endotoxic shock and host defence afforded by an immunomodulatory muropeptide.

Project description:Transcriptional profiling of intestinal response to Citrobacter rodentium in wild-type and Nlrp12-deficient mice Four-conditions experiment, Nlrp12-deficient mouse infected by Citrobacter rodentium at day 7 versus non-infected Nlrp12-deficient mice with two biologicals replicates , Wild-type mouse infected by Citrobacter rodentium at day 7 versus non-infected Wild-type mice with two biologicals replicates and Nlrp12-deficient mouse infected by Citrobacter rodentium versus Control mouse infected by Citrobacter rodentium at 2 differents times ( day 0 and post infection at day 7 ) with three biologicals replicates

2015-07-25 | E-GEOD-59940 | biostudies-arrayexpress

The Nlrp12 inflammasome negatively regulates NOD2-mediated adjuvanticity, endotoxic shock and host defence afforded by an immunomodulatory muropeptide.

Project description:Transcriptional profiling of intestinal response to Citrobacter rodentium in wild-type and Nlrp12-deficient mice

2015-07-25 | GSE59940 | GEO

RNAseq analysis of gene expression in colorectal tumors of wild-type and Nlrp12-/- mice

Project description:Background: NLRP12 is a cytosolic pattern recognition receptor in the family of NOD-like receptor. NLRP12 has been shown to suppress colorectal tumorigenesis. However, the precise mechansim of NLRP12-mediated regualtion of colorectal cancer is unknown. Results: RNAseq data demonstrate higher expression of oncogenes, matrix degrading enzymes such as matrix metaloproteinases (MMPs), and genes involved in tumor invasion in Nlrp12-/- compared to wild-type tumors. Notably, several of the genes highly induced in Nlrp12-/- tumors are regulated by the Wnt/b-catenin pathway. Conclusion: NLRP12 negatively regualtes the Wnt/b-catenin pathway to suppress colorectal cancer progression and invasion.

2020-10-01 | GSE149769 | GEO

Nlrp12 expressing heamatopoitic cells maintain the intestinal microbiome symbiosis.

Project description:Nlrp12-/- mice host a dysbiotic microbiome. After performing bone marrow transplantation study, we found mice receiving Nlrp12-/- haematopoitic cells pheno-copied the dysbiotic microbiome in the Nlrp12-/- mice.

| PRJEB18700 | ENA

microbiome difference of high fat diet fed WT and Nlrp12 ko mice in the vivarium 2

Project description:microbiome difference of high fat diet fed WT and Nlrp12 ko mice in the vivarium 2

| PRJEB26986 | ENA

Project description:Role of NLRP12 in B6/lpr Mice

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Gene expression difference between normal and Pten-deficient 5-HT neurons

Project description:Purpose: compare the gene expression diffenrence between wildtype and Pten-deficient 5-HT neurons. Methods: 5-HT neurons cell body are collected from acut brain slice with patch electrodes. Pten-deficient 5-HT neurons are obtained from Pet1-Cre; Ptenflox/flox mice. Normal 5-HT neurons are obtained from littermate wildtype mice. Reverse transcription was performed using a SMARTer Ultra Low RNA Kit (Clontech, Japan). Single-cell cDNA was amplified using an Advantage 2 PCR Kit (Clontech, Japan). Purified cDNA from individual cells were sequenced using the Illumina HiSeq 2000 platform. Sequence reads were aligned to the mouse mm9 genome using TopHat. Differential expression analysis was performed using DESeq (Bioconductor) followed by Student t-test. Genes were considered differentially expressed if p<0.05. Results: The somatic compartments of individual YFP-labeled 5-HT neurons in acute brain slices were harvested for RNA sequencing. Each of the cells had 2 X 107 reads mapping back to the mouse genome when analyzed using the RUM mapping program. We found 859 genes (381 up-regulated, 478 down-regulated) were differentially expressed in Pten-deficient 5-HT neurons. Gene ontology of differentially expressed genes revealed the biological processes up-regulated and down-regulated in Pten-deficient 5-HT neurons. The absence of Pten in 5-HT neurons was associated with significantly increased expression of genes involved in the regulation of axonal extension and cell size, cell morphogenesis and cytoskeleton organization

2021-01-12 | GSE164610 | GEO

Murine Liver Cells: Control B6 males vs. little (GH-deficient) and Tfm (AR-null) males

Project description:Transcriptional profiling of mouse whole liver comparing control WT B6 mice with B6 growth hormone-deficient little, B6 androgen receptor-null Tfm mice, and STAT5b KOs normalized to WT on B6 and BALB/c backgrounds. All animals were 10-week-old males initiated with DEN. Oberley et al. Molecular carcinogenesis 2014 May 17. doi: 10.1002/mc.22165.

2014-08-09 | GSE60253 | GEO

NLRP12 WT and KO mice fecal samples

Project description:NLRP12 WT and KO mice fecal samples Raw 16S rRNA sequence reads

| PRJNA512540 | ENA

Restoring dysbiotic microbiome in the Nlrp12-/- mice

Project description:Three studies, including cohousing, Infliximab (anti-TNF)and Tocilizumab (anti-IL6r) and Lachnospiraceae strains treatments were performed to investigate how to restoring the dysbiotic microbiome in the Nlrp12-/- mice.

| PRJEB18699 | ENA

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