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The genome sequence of the murine whipworm Trichuris muris

ABSTRACT: The genome sequence of the murine whipworm Trichuris muris

PROVIDER: PRJEB2108 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR021973_1.fastq.gz	Fastqsanger.gz
	ERR021973_2.fastq.gz	Fastqsanger.gz
	ERR037216_1.fastq.gz	Fastqsanger.gz
	ERR037216_2.fastq.gz	Fastqsanger.gz

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The genome sequence of the murine whipworm Trichuris muris

Project description:Project to produce a reference quality genome of Trichuris muris, a model whipworm.

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Project description:Trichuris muris, the mouse whipworm is used as a laboratory model of the human parasite T. trichuira - a gastrointestinal nematode. Three laboratory isolates of T. muris exist: the E, J and S isolates. Previous data has shown that the S isolate survives to chronicity in C57BL/6 mice unlike the E and J isolates which are expelled. The ability of the S isolate to persist is still unclear. Microarray analysis of gut samples from mice infected with either the E or S isolates of T. muris for 7 days was used to determine early changes in gene expression that may later determine the outcome of infection.

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Project description:This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ The human-infective whipworm Trichuris trichiura is estimated to infect up to a billion people and is responsible for considerable morbidity, especially in children of developing countries. The closely related species T. muris is a naturally occurring nematode parasite of mice that serves as a remarkably tractable model system for dissecting immune responses and host-parasite relationships. Such studies are of relevance beyond parasitology as helminths have arguably had a significant impact on the evolution of the mammalian immune system. Both Trichuris species reside in the caecum and colon of the host where they burrow their front end for feeding into the intestinal mucosa, thereby breaching the mucus barrier and allowing access of the microflora directly to the epithelium. The interplay of intestinal helminths, the bacterial microflora and the host immune system is currently a research focus in various laboratories (Bancroft et al 2012). This study will study the transcriptional responses of the intestinal mucosa (caecum) from infected and uninfected mice.

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