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SHIP-Microbiome Interactions in Intestinal Inflammation

ABSTRACT: SHIP-deficient mice develop spontaneousl ileitis beginning at 6 weeks of age. We sequenced the 16S rRNA gene of 8 week and 4 week old mouse intestinal content samples to investigate if and when changes to the microbiome occur.

PROVIDER: PRJEB26422 | ENA |

REPOSITORIES: ENA

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Cardiorenal Effects of Peritoneal Dialysis in the 5/6Nx Uremic Rat Model

Project description:In this study we compare transcriptomic changes in the kidney and left ventricle in response to peritoneal dialyisis exchanges performed 3x per day for 8 days beginning 6 weeks after 5/6 nephrectomy or sham surgery in 10 week old male Sprague Dawley rats. .

2022-07-08 | GSE207524 | GEO

The Alzheimer’s disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology [snRNA-seq]

Project description:INTRODUCTION: Gain-of-function mutations in INPP5D, which encodes for the SH2-domain-containing inositol phosphatase SHIP-1, have recently been linked to an increased risk of developing late-onset Alzheimer’s disease (LOAD). Yet, little is currently known in regards to how SHIP-1 affects neurobiology or neurodegenerative disease pathogenesis. METHODS: To bridge this knowledge gap, we generated 5xFAD Inpp5dfl/flCx3cr1Ert2Cre mice to investigate the function of microglial SHIP-1 signaling in response to amyloid beta (Aβ)-mediated pathology. RESULTS: In our studies, we found that SHIP-1 deletion in microglia leads to substantially enhanced recruitment of microglia to Aβ plaques, altered microglial gene expression, and marked improvements in neuronal health. Further, SHIP-1 loss enhanced microglial plaque containment and Aβ engulfment when compared to microglia from Cre-negative 5xFAD Inpp5dfl/fl littermate controls. DISCUSSION: These results define SHIP-1 as a pivotal regulator of microglial responses during Aβ-driven neurological disease.

2023-04-15 | GSE220279 | GEO

Comparison of mammary glands of 16 wk old wild type and LH-overexpressing mice

Project description:LH-overexpressing mice display elevated levels of mammogenic hormones and consequently develop spontaneous mammary tumors with a median latency of 41 weeks. Tumors occur in the absence of p53 mutations and in the presence of a seemingly functional p53 signaling pathway. At 16 weeks of age, no histological evidence of tumors is observed in these transgenic mammary glands; however, mammary cells do demonstrate centrosome amplification at this age suggesting that early tumorigenic processes may have occured. Thus comparison of the transcriptome of the mammary glands from 16 week old LH-overexpressing mice to that of wild type mice will provide insight into early events occuring in p53-independent hormone-induced tumorigenesis. Keywords: disease state analysis

2005-10-10 | GSE3348 | GEO

Gene expression profiling of s-SHIP positive mammary epithelial cells

Project description:We performed RNAseq on subpopulations of mammary epithelial cells. We carried out sorting of a gradient of s-SHIP positive cells in the mammary gland (neg, low, and hi for s-SHIP eGFP). High sSHIP-eGFP populations denote a postulated stem cell population, while low and negative represent more differentiated cell types. s-SHIP eGFP hi to negative potentially represents a gradient from stem to more differentiated progeny, respectively, within the basal epithelial compartment. We FACS sorted 3 replicates for each cell type to represent s-SHIP-neg, s-SHIP-low, and s-SHIP-high.

2017-11-07 | GSE81385 | GEO

RNA-Sequencing reveals mechanisms by which human glial progenitor cells (hGPCs) initiate remyelination

Project description:To investigate transcriptomic drivers of human myelination, immunodeficient mice were chimerized with fetal derived hGPCs at P1, sacrified at 36 weeks, and hGPCs were extracted for RNA-Sequencing via FACS. Mice were either fed a control diet for the entireity of their lives or a demyelinating diet beginning at 12 weeks of age until 24 weeks, when they were transitioned to a control diet to allow for remyelination to begin.

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Acute and long-term responses to radiation in zebrafish

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2014-04-01 | E-GEOD-46026 | biostudies-arrayexpress

GNPS - Colgate facial cleanser longitudinal study_Skin samples

Project description:MS/MS spectra were collected from face of 6 individuals before and during 2 weeks of application of a Colgate facial cleanser. During weeks 1-4 of washout period, volunteers did not use any personal beauty product and they washed their face only with water. During the following 2 weeks, all participants applied the Colgate facial cleanser daily on their face. Samples were collected at the end of the washout period on week 4. During facial cleanser application (weeks 5 and 6), samples were collected once a week (beginning of week 5 and end of week 6) right after the first usage then 4, 8 and 24 hours after the first usage. For each timepoint, 9 samples were collected from different locations on the face.

2018-06-01 | MSV000082432 | GNPS

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Differentially expressed genes in livers and abdominal fats between normal- and high-fat diet-fed chickens

Project description:To investigate genes involved in abdominal fat deposition and fat metabolism of broilers, we used highthroughput sequencing to detect the differentially expressed genes in livers and abdominal fats of broilers which were fed with a normal diet and a high-fat diet, respectively. The broilers began to fed with a normal or a high-fat diet in 1-week-old. After 7 weeks, the broilers were be executed and the livers and abdominal fats were used to extracted total RNAs. Finally, the total RNAs were be sequenced used BGISEQ-500 platform.

2019-03-16 | GSE128340 | GEO

Differentially expressed genes in livers and abdominal fats between normal- and high-fat diet-fed dwarf broilers

Project description:To investigate genes involved in abdominal fat deposition and fat metabolism of broilers with dw gene, we used highthroughput sequencing to detect the differentially expressed genes in livers and abdominal fats of dwarf broilers which were fed with a normal diet and a high-fat diet, respectively. The broilers began to fed with a normal or a high-fat diet in 1-week-old. After 7 weeks, the broilers were be executed and the livers and abdominal fats were used to extracted total RNAs. Finally, the total RNAs were be sequenced used BGISEQ-500 platform.

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