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WGS of OXA-48-producing K. pneumoniae

ABSTRACT: Whole-genome analysis of endemic OXA-48-producing K. pneumoniae clinical isolates in Catalonia, Spain

PROVIDER: PRJEB27508 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2673190_1.fastq.gz	Fastqsanger.gz
	ERR2673190_2.fastq.gz	Fastqsanger.gz
	ERR2673200_1.fastq.gz	Fastqsanger.gz
	ERR2673200_2.fastq.gz	Fastqsanger.gz
	ERR2673210_1.fastq.gz	Fastqsanger.gz

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NDM-1 and OXA-48-Like Carbapenemases (OXA-48, OXA-181 and OXA-252) Co-Producing <i>Shewanella xiamenensis</i> from Hospital Wastewater, China.

Project description:BackgroundShewanella genus, as an important carrier of resistance genes, has the potential to transmit resistance to many antimicrobials in many circumstances, especially in aquatic environment. The aim of the study was to describe the risk of Shewanella xiamenensis in hospital environment through analysis of genomic comparison and resistance status.MethodsSeven S. xiamenensis strains were isolated from hospital wastewater. PCR and Sanger sequencing were carried out for detection of common carbapenemase genes. Antimicrobial susceptibility testing was performed to determine the antimicrobial profile. Whole genome sequencing was applied, and sequences were further used for genomic analysis.ResultsSeven Shewanella xiamenensis were all positive for bla NDM and bla OXA-48. Antimicrobial susceptibility testing showed all Shewanella xiamenensis were resistant to cefotaxime, ceftazidime, imipenem, meropenem, gentamycin and trimethoprim-sulfamethoxazole. Whole genome sequencing and phylogenetic analysis demonstrated the diversity of Shewanella xiamenensis despite isolating from one wastewater pool.ConclusionTo the best of our knowledge, this is the first report of detection of three types bla OXA-48-like genes in one hospital in China. And we have detected multi-drug resistant S. xiamenensis from hospital wastewater. This emphasizes that the presence of naturally existing carbapenemases in the environment may be significantly overlooked and that the bla OXA-48-like genes in China may originate through the horizontal gene transfer from S. xiamenensis to Enterobacterales rather than import from other countries.

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