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Keratinocyte expression of Mcpip1 is essential for the maintenance of skin integrity

ABSTRACT: Keratinocyte expression of Mcpip1 is essential for the maintenance of skin integrity and for the control of local and systemic inflammation

PROVIDER: PRJEB31970 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3310280.fastq.gz	Fastqsanger.gz
	ERR3310281.fastq.gz	Fastqsanger.gz
	ERR3310282.fastq.gz	Fastqsanger.gz
	ERR3310283.fastq.gz	Fastqsanger.gz
	ERR3310284.fastq.gz	Fastqsanger.gz

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Distinct roles of keratinocyte- and myeloid- MCPIP1 in maintaining skin homeostasis

Project description:The morphology of the skin changes upon depletion of MCPIP1 in cells of myeloid origin as well as in keratinocytes. The thicknesses of epidermal and hypodermal layers are significantly increased in mice with loss of epidermal MCPIP1, whereas loss of myeloid MCPIP1 exerts completely opposite effect. Both types of mice show contrary response to the stimulation with 12-O-tetradecanoylphorbol-13-acetate. Skin morphology and inflammatory phenotype of keratinocyte- and myeloid- double MCPIP1 knockout mice is similar to that of the single keratinocyte knockout of MCPIP1. In all, myeloid and epidermal MCPIP1 play significant but distinct roles in the modulation of skin-related processes.

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