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Factors affecting the gut bacterial diversity might change the effectiveness of therapeutic helminth

ABSTRACT: We studied the microbiome of fecal samples from rats treated or untreated with both antibiotics and chemically-induced colitis, and infected or uninfected with the symbiont Hymenolepis diminuta.

PROVIDER: PRJEB35048 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3697800_1.fastq.gz	Fastqsanger.gz
	ERR3697800_2.fastq.gz	Fastqsanger.gz
	ERR3697810_1.fastq.gz	Fastqsanger.gz
	ERR3697810_2.fastq.gz	Fastqsanger.gz
	ERR3697820_1.fastq.gz	Fastqsanger.gz

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Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

Project description:Mouse infection with the tapeworm Hymenolepis diminuta leads to a less severe DNBS-colitis. Increased Th2 and regulatory cytokine production in the spleen is a hallmark of Hymenolepis diminuta infection, therefore we hypothesized that given this microenvironment, splenic adaptive cells acquire an anti-inflammatory phenotype. We tested the ability of putative splenic regulatory B cells generated by Hymenolepis diminuta infection to down-regulate intestinal inflammation. We found that unlike splenic B cells from uninfected mice, splenic B cells from Hymenolepis diminuta -infected animals ameliorated chemically-induced colitis.

2015-02-20 | GSE61460 | GEO

Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

2015-02-20 | E-GEOD-61460 | biostudies-arrayexpress

Hymenolepis diminuta

Project description:Hymenolepis diminuta overview

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Cestode Antigens Block LPS-induced Inflammatory Mediators and Condition Macrophages to Educate Anti-colitic T Cells

Project description:We tested the ability of rat worm Hymenolepis diminuta parasite crude antigens (HdAg) to induce a regulatory-associated program in bone-marrow derived macrophages (BMMs). Also, we compared gene expression profile of BMMs exposed to HdAg with those exposed to IL-4 which elicits a well-known alternative program.

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Project description:Hymenolepis diminuta Transcriptome or Gene expression

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Comparative genomics of Hymenolepis diminuta strains

Project description:Hybrid sequencing of Hymenolepis diminuta genome

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Transcriptome sequencing of Hymenolepis microstoma a classic laboratory model in cestodology

Project description:Hymenolepis spp. (H. diminuta, H. nana and H. microstoma) are rodent-hosted tapeworms (Platyhelminthes: Cestoda) that have been used as laboratory and teaching models since the 1950s, and consequently much of our understanding of the basic physiology, biochemistry and anatomy of tapeworms in general stems from research using these species. As representatives of the order Cyclophyllidea, they are closely related to species with significant medical and economic importance such as Taenia and Echinococcus spp., but unlike these may be maintained in vivo using only laboratory mice and flour beetles (n.b. Echinoccous spp. are hosted by foxes and Taenia spp. are hosted by pigs or cows). This effort brings a classical laboratory model into the genomic age, allowing researchers in silico access to its genome and expressed gene transcripts and thereby greatly expediting research directed at understanding the genetic basis of tapeworm biology.

2013-01-28 | E-ERAD-56 | biostudies-arrayexpress

Proteomics and immunoproteomics of Anoplocephala perfoliata

Project description:Anoplocephala perfoliata is a common tapeworm in horse with an ability to cause colic and increase mortality. At present, current diagnostic methods are not sensitive enough to detect A. perfoliata and immunoreactive excretory/secretory (E/S) proteins produced by this parasite, which comprise the most promising candidates for diagnostic tests. Here, we compared the E/S proteins produced by A. perfoliata worms of two different physiological states (small- and large-sized worms) in vitro by label-free quantitative (LFQ) proteomics with protein database composed of proteins encoded by Hymenolepis diminuta, Echinococcus multilocularis/granulosus and Taenia aseatica for protein identifications. The quantitative proteomics data was complemented with one-dimensional gel electrophoresis combined with immunoblotting using antisera from horses diagnosed positive and negative for this tapeworm. Protein bands cross-reacting most efficiently with the anti-A. perfoliata antibodies were subjected to in-gel digestion with LC-MS/MS identification. Both the non-gel and gel-based proteomic results were compared to propose a list of candidate proteins for further studies. These proteins will be validated for their suitability as diagnostic markers specific to cestodes and A. perfoliata.

2022-11-11 | PXD029144 | Pride

Gene expression of Rickettsia infected green rice leafhopper Nephotettix cincticeps.

Project description:The green rice leafhopper Nephotettix cincticeps have two mutualistic symbiotic bacteria (Candidatus Sulcia muelleri and Candidatus Nasuia deltocephalinicola) in its symbiont special organ bacteriome and are also infected to rickettsia. In order to determine immune challenge is induced or not by rickettsia infection in N. cincticeps, we investigated gene expression between rickettsia-infected and rifampicin treated uninfected N. cincticeps colonies.

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Project description:Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

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