Project description:We report the application of RNA-seq for profiling gene transcription upon treatment of dipeptidyl peptidases 8 and 9 inhibitor, Val-boroPro (VbP). We find no significant changes in gene transcription upon treatment of mammalian cells with Val-boroPro.
Project description:Morphological and molecular investigations on Cryphonectria parasitica isolates attacking chestnut in Basilicata Region (Southern Italy)
Project description:To investigate the effect of PD-1 expression on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes related to the cell proliferation of human B-cell lymphoma (HBCL) cell line VAL in vitro.
Project description:Investigations on a possible phytoplasma disease on sweet pepper from the countryside of Senise, Basilicata Region, southern Italy.
Project description:Investigations on a possible phytoplasma disease on sweet pepper from the countryside of Senise, Basilicata Region, southern Italy.
Project description:To date, total mRNA analysis throughout intraerythrocytic development of the malaria parasite, Plasmodium falciparum, has only revealed abundance profiles of each gene at a given time. Here, we reveal that biosynthetic pyrimidine labeling allows for the calculation of real-time, whole-genome analysis of transcription and stability throughout asexual development. In turn, we are now able to determine transcriptional and decay rates at any given time during development of specific genes or subsets of genes which will drive new investigations on both transcriptional and post-transcriptional regulatory dynaimc and networks.