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Exome-Seq of murine MB49 cell line - WT and gal-9-KO - in vitro

ABSTRACT: Exome-Seq of murine MB49 cell line - WT and gal-9-KO - in vitro

PROVIDER: PRJEB41649 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR4901810_1.fastq.gz	Fastqsanger.gz
	ERR4901810_2.fastq.gz	Fastqsanger.gz
	ERR4901811_1.fastq.gz	Fastqsanger.gz
	ERR4901811_2.fastq.gz	Fastqsanger.gz
	ERR4901812_1.fastq.gz	Fastqsanger.gz

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Exome-Seq of murine MB49 cell line - WT and gal-9-KO - in vitro

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RNAseq of murine MB49 tumors - WT and gal-9-KO - grown on C57BL/6 syngenic mice through serial transplantations

Project description:A number of studies have reported evidence of positive or negative contributions of galectin-9 (gal-9) to human and experimental malignancies. Some clinical observations and in vitro experiments suggest that cell-associated gal-9 has anti-metastatic effects. On the other hand, extra-cellular gal-9 consistently enhances tumor immune escape. So far, all animal studies on this subject have been focused on gal-9 released by infiltrating cells, without paying attention to gal-9 released by malignant cells. To address this issue, we derived by gene editing, isogenic clones - either positive or negative for gal-9 - from the MB49 murine bladder carcinoma cell line. A progressive reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngenic mice but not into nude mice thus accounting the tumor growth reduction in syngenic mice to a better immune response. Tumor fragments were collected from WT and KO tumors at different steps of the experiment : 2nd growth cycle (WT = 5 samples ; KO = 6 samples ) ; 3rd growth cycle (WT = 5 samples ; KO = 7 samples) ; 4th growth cycle (WT = 4 samples ; KO = 3 samples), in order to study the differences between WT and KO tumors through the serial transplantations, by RNAseq analysis.

2020-07-01 | E-MTAB-9220 | biostudies-arrayexpress

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Project description:RNAseq of murine CT26 cell line -WT and gal-9-KO - in vitro

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Project description:Galectin-1 (Gal-1) and Galectin-3 (Gal-3) are conserved carbohydrate-binding proteins that also display RNA-binding activity. We generated mouse embryonic stem cells (mESC) constitutively depleted of Gal-1 and/or Gal-3 using CRISPR-Cas9, and assessed the transcriptomic effects of the individual or concomitant depletion of Gal-1 and Gal-3 in mESCs differentiated by deprivation of the leukaemia inhibitory factor (LIF) for 7 days. Wild-type cells were employed as control.

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