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Trichuris muris infection drives cell-intrinsic IL4R alpha independent large intestinal RELMα+ macrophages.

ABSTRACT: Trichuris muris infection drives cell-intrinsic IL4R alpha independent large intestinal RELMα+ macrophages.

PROVIDER: PRJEB45349 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR5983840_1.fastq.gz	Fastqsanger.gz
	ERR5983840_2.fastq.gz	Fastqsanger.gz
	ERR5983841_1.fastq.gz	Fastqsanger.gz
	ERR5983841_2.fastq.gz	Fastqsanger.gz
	ERR5983842_1.fastq.gz	Fastqsanger.gz

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Trichuris muris infection drives cell-intrinsic IL4R alpha independent large intestinal RELMα+ macrophages.

Project description:The RELMα+ macrophage phenotype associates with the presence of anti-inflammatory macrophages and work in other model systems has demonstrated that the balance of pro-inflammatory and anti-inflammatory macrophages is critically important in enabling the resolution of inflammation. Moreover, in the context of type 2 immunity, RELMα+ anti-inflammatory macrophages are associated with the activation of macrophages via the IL4Ra. Despite a breadth of inflammatory pathologies associated with the large intestine, including those that accompany parasitic infection, it is not known about how large intestinal macrophages are activated towards an anti-inflammatory phenotype.

2021-11-15 | E-MTAB-10501 | biostudies-arrayexpress

Trichuris muris transcriptomics

Project description:Trichuris muris is very closely related to the human parasite T. trichiura sharing cross reactive antigens. Moreover, it is a remarkably tractable model system for dissecting immune responses and host parasite relationships and is actively being investigated in a number of laboratories worldwide. T. muris is a naturally occurring nematode parasite of mice which resides in the caecum and colon and has a direct oral faecal life cycle. High-throughput sequencing of Trichuris muris transcriptome for de novo assembly of transcripts. The main objective of this project is to recognize genes expressed in given life stages. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

2013-05-28 | E-ERAD-125 | biostudies-arrayexpress

Trichuris muris

Project description:Trichuris muris overview

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Project description:We analysed the exosomes secreted by the nematode Trichuris muris. Two replicates of exosomes were analysed using a 5600+ mass spectrometer

2017-12-13 | PXD008387 | Pride

miRNA data from extracellular vesicles secreted by Trichuris muris

Project description:miRNA-Seq analysis of the miRNA present in the extracellular vesicles secreted by the nematode Trichuris muris

2017-12-13 | GSE107985 | GEO

mRNA data from extracellular vesicles secreted by Trichuris muris

Project description:RNA-Seq analysis of the mRNA present in the extracellular vesicles secreted by the nematode Trichuris muris

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Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages.

Project description:The intestinal nematode parasite Trichuris muris dwells in the caecum and proximal colon driving an acute resolving intestinal inflammation dominated by the presence of macrophages. Notably, these macrophages are characterised by their expression of RELMα during the resolution phase of the infection. The RELMα+ macrophage phenotype associates with the presence of alternatively activated macrophages and work in other model systems has demonstrated that the balance of classically and alternatively activated macrophages is critically important in enabling the resolution of inflammation. Moreover, in the context of type 2 immunity, RELMα+ alternatively activated macrophages are associated with the activation of macrophages via the IL4Rα. Despite a breadth of inflammatory pathologies associated with the large intestine, including those that accompany parasitic infection, it is not known how colonic macrophages are activated towards an alternatively activated phenotype. Here, we address this important knowledge gap by using Trichuris muris infection, in combination with transgenic mice (IL4Rαfl/fl.CX3CR1Cre) and IL4Rα-deficient/wild-type mixed bone marrow chimaeras. We make the unexpected finding that education of colonic macrophages towards a RELMα+, alternatively activated macrophage phenotype during T. muris infection does not require IL4Rα expression on macrophages. Further, this independence is maintained even when the mice are treated with an anti-IFNγ antibody during infection to create a strongly polarised Th2 environment. In contrast to RELMα, PD-L2 expression on macrophages post infection was dependent on IL4Rα signalling in the macrophages. These novel data sets are important, revealing a surprising cell-intrinsic IL4R alpha independence of the colonic RELMα+ alternatively activated macrophage during Trichuris muris infection.

| S-EPMC8357096 | biostudies-literature

Extracellular vesicles from Heligmosomoides bakeri and Trichuris muris contain distinct small RNAs

Project description:We report the small RNA content of extracellular vesicles (EVs) from adult parasite Trichuris muris and Heligmosomoides bakeri

2020-08-01 | GSE152591 | GEO

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Project description:We measured the gene expression differences in germinal centre B cells from day 13 Trichuris muris-infected mice in which MLL1 is conditionally deleted in mature B cells

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2017-05-23 | PXD006344 | Pride

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