Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gnomic investigation on biocide adaptation in Listeria monocitogenese

ABSTRACT: effect of biocide adaptation on antimicrobial resistance in Listeria monocytogenese

PROVIDER: PRJEB48925 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR7423510_1.fastq.gz	Fastqsanger.gz
	ERR7423510_2.fastq.gz	Fastqsanger.gz
	ERR7423520_1.fastq.gz	Fastqsanger.gz
	ERR7423520_2.fastq.gz	Fastqsanger.gz
	ERR7423530_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 52

Similar Datasets

Adaptation of Listeria weihenstephanensis to anaerobiosis

Project description:Adaptation of Listeria weihenstephanensis to anaerobiosis. Trascriptional profiling at two different temperatures of L. weihenstephanensis

2017-08-23 | GSE94124 | GEO

Project description:Listeria biocide resistance

| PRJNA978348 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of Listeria monocytogenes Transcriptomes

Project description:RNA-Seq was used to unravel the potential antimicrobial mechanism of linalool against Listeria monocytogenes.

2019-09-07 | GSE136998 | GEO

The response of E. coli to exposure to the biocide polyhexamethylene biguanide

Project description:The global response of E. coli tot he broad spectrum biocide polyhexamethyelene biguanide (PHMB) was investigated using transcriptional profiling. Keywords: dose response

2006-02-01 | GSE2827 | GEO

Expression analysis of Listeria monocytogenes during adaptation in soil

Project description:Investigation of whole genome gene expression level changes in Listeria monocytogenes EGD-e during incubation (0, 15 min, 30 min) in two types of soil extracts (TA, DA).

2020-01-01 | GSE29039 | GEO

Contrasting genes conferring short and long-term biofilm adaptation in Listeria

Project description:Listeria monocytogenes is an opportunistic food-borne bacterium that is capable of infecting humans with high rates of hospitalisation and mortality. Natural populations are genotypically and phenotypically variable, with some lineages being responsible for most human infections. The success of L. monocytogenes is linked to its capacity to persist on food and in the environment. Biofilms are an important feature that allow these bacteria to persist and infect humans, therefore, understanding the genetic basis of biofilm formation is key to understanding transmission. We sought to investigate the biofilm forming ability of L. monocytogenes by identifying genetic variation that underlies biofilm formation in natural populations using genome-wide association studies. Changes in gene expression of specific strains during biofilm formation were then investigated using RNAseq. Genetic variation associated with enhanced biofilm formation was identified in 273 genes by GWAS and differential expression in 220 genes by RNAseq. Statistical analyses show that number of overlapping genes flagged by either type of experiment is less than expected by random sampling. This is consistent with an evolutionary scenario where rapid adaptation is driven by variation in gene expression of pioneer genes, and this is followed by slower adaptation driven by nucleotide changes within the core genome.

2023-06-28 | GSE235979 | GEO

Listeria weihenstephanensis

Project description:Adaptation of Listeria weihenstephanensis to anaerobiosis

| PRJNA368986 | ENA

ISG15 counteracts Listeria monocytogenes infection

Project description:ISG15 is primarily documented as an interferon-stimulated, ubiquitin-like protein (ubl), which has anti-viral activity. Although ISG15 was the founding member of the ubl protein family, very little is known about its function. We have found that ISG15 expression in non-phagocytic cells is dramatically induced upon Listeria infection and that surprisingly this induction can be Type I Interferon independent. Listeria-mediated ISG15 induction depends on the cytosolic surveillance pathway, which senses bacterial DNA and signals through STING, TBK1, IRF3 and IRF7. Most importantly, we observed that ISG15 expression restricts Listeria infection both in vitro and in vivo. We then made use of Stable Isotope Labeling in tissue culture (SILAC) to identify the ISGylated proteins that could be responsible for the ISG15-mediated protective effect. Our SILAC analysis revealed that overexpression of ISG15 leads to a striking ISGylation of integral membrane proteins of the endoplasmic reticulum and Golgi apparatus, which correlates with increased canonical secretion of cytokines. Taken together, our data reveal a previously uncharacterized signaling pathway that restricts Listeria infection and acts via ISGylation, reinforcing the view that ISG15 is a key component of the innate immune arsenal of the mammalian host.

2015-07-24 | PXD001805 | Pride

Proteomic adaptation of Streptococcus pneumoniae to the human antimicrobial peptide LL-37

Project description:Secreted antimicrobial peptides (AMPs) are an important part of the human innate immune system and prevent local and systemic infections by inhibiting bacterial growth in a concentration dependent manner. In the respiratory tract, the cationic peptide LL-37 is one of the most abundant AMPs and capable of building pore complexes in usually negatively charged bacterial membranes, leading to destruction of bacteria. However, adaptation mechanisms of several pathogens to LL-37 are already described and are known to weaken the antimicrobial effect of the AMP, for instance, by repulsion, export or degradation of the peptide. This study examines proteome wide changes in Streptococcus pneumoniae D39, the leading cause of bacterial pneumonia, in response to physiological concentrations of LL-37 by high resolution mass spectrometry. Our data indicate that pneumococci may use some of the known adaptation mechanisms to reduce the effect of LL-37 on their physiology, too. Additionally, several proteins seem to be involved in resistance to AMPs which have not been related to this process before, such as the teichoic acid flippase TacF (SPD_1128). Understanding colonization and infection relevant adaptations of the pneumococcus to AMPs, especially LL-37, could finally uncover new drug targets to weaken the burden of this widespread pathogen.

2020-03-19 | PXD016511 | Pride

Transcription profiling of Listeria monocytogenes following oxygen restriction

Project description:Effect of Oxygen restriction on infection potential of Listeria monocytogenes

2010-07-01 | E-MEXP-2279 | biostudies-arrayexpress