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Host transcriptome response to Lumpy Skin Disease (LSD) infection depends on the challenging virus strain

ABSTRACT: Host transcriptome response to Lumpy Skin Disease (LSD) infection depends on the challenging virus strain

PROVIDER: PRJEB62430 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR11453654_1.fastq.gz	Fastqsanger.gz
	ERR11453654_2.fastq.gz	Fastqsanger.gz
	ERR11453655_1.fastq.gz	Fastqsanger.gz
	ERR11453655_2.fastq.gz	Fastqsanger.gz
	ERR11453656_1.fastq.gz	Fastqsanger.gz

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Host transcriptome response to Lumpy Skin Disease (LSD) infection depends on the challenging virus strain

Project description:Ten cattle have been challenged with two Lumpy Skin Disease Virus (LSDV). They were sampled for whole blood immediately before (pre) and three and seven days after (post) infection challenge with two virus strains (H vs. O). The whole RNA-sequencing was done, and 150bp paired reads were assembled as the transcriptome. It was then computationally analyzed to find the differentially expressed genes (DGE) that enrich the gene ontology (GO) terms and KEGG pathways. Depending on the challenged LSDV strain, they influence the host response differently.

2023-06-15 | E-MTAB-12965 | biostudies-arrayexpress

Host transcriptome profiling of the Lumpy Skin Disease (LSD) for resilience and susceptibility

Project description:Lumpy Skin Disease (LSD) is an endemic viral infection in Africa, newly emerging in Europe and becoming a global threat. There is host variation in response to infections in field studies and under carefully controlled artificial infections. It’s sometimes around 50% in clinical trials. This study aims to understand the mechanisms underlying this diversity and find the determinants to distinguish between susceptible (recovered) and resistant (non-recovered) animals through Differential Gene Expression (DGE) analysis. Five approximately 6-month-old male Holstein bulls were experimentally infected with LSDV. RNA sequencing was done for whole blood samples collected five days prior (pre-infection) to 3, 7, and 15 days after the infection (post-infection) challenge. After the challenge, two animals recovered, and three did not.

2023-01-28 | E-MTAB-12547 | biostudies-arrayexpress

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Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia [RNA-seq]

Project description:Chronic administration of lysergic acid diethylamide (LSD) every other day to rats results in a variety of abnormal behaviors. These build over the 90 day course of treatment and can persist at full strength for at least several months after cessation of treatment. The behaviors are consistent with those observed in animal models of schizophrenia and include hyperactivity, reduced sucrose-preference, and decreased social interaction. In order to elucidate molecular changes that underlie these aberrant behaviors, we chronically treated rats with LSD and performed RNA-sequencing on the medial prefrontal cortex (mPFC), an area highly associated with both the actions of LSD and the pathophysiology of schizophrenia and other psychiatric illnesses. Results: We observed widespread changes in the neurogenetic state of treated animals four weeks after cessation of LSD treatment. QPCR was used to validate a subset of gene expression changes observed with RNA-Seq, and confirmed a significant correlation between the two methods. Functional clustering analysis indicates differentially expressed genes are enriched in pathways involving neurotransmission (Drd2, Gabrb1), synaptic plasticity (Nr2a, Krox20), energy metabolism (Atp5d, Ndufa1) and neuropeptide signaling (Npy, Bdnf), among others. Many processes identified as altered by chronic LSD are also implicated in the pathogenesis of schizophrenia, and genes affected by LSD are enriched with putative schizophrenia genes. Our results provide a relatively comprehensive analysis of mPFC transcriptional regulation in response to chronic LSD, and indicate that the long-term effects of LSD may bear relevance to psychiatric illnesses, including schizophrenia.

2021-11-11 | GSE179379 | GEO

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