Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pasteurized Akkermansia muciniphila improves IBS-like symptoms

ABSTRACT: This study assesses the potential of a treatment with pasteurized Akkermansia muciniphila on alleviating IBS-like symptoms

PROVIDER: PRJEB68376 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Akkermansia muciniphila

Project description:Akkermansia muciniphila overview

| PRJNA36235 | ENA

Akkermansia muciniphila proteome.

Project description:Akkermansia muciniphila, a common member of the human gut microbiota, is considered to be a beneficial resident of the intestinal mucus layer. Surface-exposed molecules produced by this organism likely play important roles in colonization and communication with other microbes and the host, but the protein composition of the outer membrane has not been characterized thus far. Herein we identify A. muciniphila proteins after enrichment and fractionation of the outer membrane proteome of A. muciniphila.

2016-09-27 | PXD004400 | Pride

Mass spectrometry identification of Akkermansia muciniphila -Caco2 cells interaction proteins

Project description:Akkermansia muciniphila is recognized as a promising probiotic that improves the symptoms of a variety of diseases. However, the role and mechanism of A. muciniphila in regulating intestinal homeostasis remain to be explored. Here, we discovered that A. muciniphila was dramatically increased during colitis recovery, and its colonization greatly increased goblet cells to protect the intestinal barrier in mice. Amuc_0904, a previously uncharacterized A. muciniphila outer membrane protein, was identified to induce goblet cell differentiation.We want to find the receptors that 904 interacts with cells to explore the detailed mechanism.

2024-09-02 | PXD055466 | Pride

Binding of Akkermansia muciniphila to mucin is O-glycan specific

Project description:The intestinal anaerobic bacterium Akkermansia muciniphila is specialized in the degradation of mucins, which are heavily O-glycosylated proteins that constitute the major components of the mucus lining the intestine. Despite that adhesion to mucins is considered critical for the persistence of A. muciniphila in the human intestinal tract, our knowledge of how this intestinal symbiont recognizes and binds to mucins is still limited. Here, we first show that the mucin-binding properties of A. muciniphila are independent of environmental oxygen concentrations and not abolished by pasteurization. We then dissected the mucin-binding properties of pasteurized A. muciniphila by use of a recently developed cell-based mucin array that enables display of the tandem repeats of human mucins with distinct O-glycan patterns and structures. We found that A. muciniphila recognizes the unsialylated LacNAc (Galβ1-4GlcNAc1-R) disaccharide selectively on core2 and core3 O-glycans. This disaccharide epitope is abundantly found on human colonic mucins capped by sialic acids, and we demonstrated that endogenous A. muciniphila neuraminidase activity can uncover the epitope and promote binding. In summary, our study provides insights into the mucin-binding properties important for colonization of a key mucin-foraging bacterium.

2024-05-30 | PXD051738 | Pride

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA1145077 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA921972 | ENA

Akkermansia muciniphila Membrane Protein Improves Cognitive Function in Aged Mice by Reducing IL-6 Expression

Project description:We implemented transcriptomic analyses of blood and hippocampus of old mice treated with Akkermansia muciniphila Membrane Protein for 8 weeks.

2023-08-25 | GSE162123 | GEO

Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

Project description:Total RNA from ileum of three groups of mice are sequenced. The three groups are 1. wild type mice. 2. mice with IFNg gene knockout. 3. IFNg gene knockout mice after colonization of Akkermansia muciniphila

2015-06-05 | E-MTAB-3633 | biostudies-arrayexpress

Akkermansia muciniphila

Project description:Akkermansia muciniphila Raw sequence reads

| PRJNA1207792 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Raw sequence reads

| PRJNA1112731 | ENA