Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of IFNg and Akkermansia muciniphila on mouse gut microbiome composition

ABSTRACT: effect of IFNg and Akkermansia muciniphila on mouse gut microbiome composition

PROVIDER: PRJEB9551 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR1736270.fastq.gz	Fastqsanger.gz
	ERR1736280.fastq.gz	Fastqsanger.gz
	ERR1736290.fastq.gz	Fastqsanger.gz
	ERR1736300.fastq.gz	Fastqsanger.gz
	ERR1735891.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

Project description:Total RNA from ileum of three groups of mice are sequenced. The three groups are 1. wild type mice. 2. mice with IFNg gene knockout. 3. IFNg gene knockout mice after colonization of Akkermansia muciniphila

2015-06-05 | E-MTAB-3633 | biostudies-arrayexpress

Multi-omics analysis reveals gut-brain interactions mediating the anti-obesity effect of Akkermansia muciniphila

Project description:Previous studies have implicated a causal role for the gut bacterium Akkermansia muciniphila in counteracting diet-induced obesity and metabolic dysfunctions. However, a systems level understanding of the molecular mechanisms underlying the anti-obesogenic effect of A. muciniphila is lacking. Using fructose-induced obese mice as a model, we carried out multiomics studies to investigate the molecular cascades mediating the effect of A. muciniphila. We found that A. muciniphila colonization in fructose-induced obese mice triggered significant shifts in gut microbiota composition as well as alterations in numerous gut and plasma metabolites and gene expression in the hypothalamus. Among these, we found that the metabolite oleoyl-ethanolamide in the gut and circulation and hypothalamic oxytocin are the key regulators of gut-brain interactions that underlie the A. muciniphila anti-obesity effect. Our multiomics investigation elucidates the molecular regulators and pathways involved in the communication between A. muciniphila in the gut and hypothalamic neurons that counter fructose-induced obesity .

2022-09-03 | GSE212491 | GEO

Akkermansia muciniphila proteome.

Project description:Akkermansia muciniphila, a common member of the human gut microbiota, is considered to be a beneficial resident of the intestinal mucus layer. Surface-exposed molecules produced by this organism likely play important roles in colonization and communication with other microbes and the host, but the protein composition of the outer membrane has not been characterized thus far. Herein we identify A. muciniphila proteins after enrichment and fractionation of the outer membrane proteome of A. muciniphila.

2016-09-27 | PXD004400 | Pride

Akkermansia muciniphila

Project description:Akkermansia muciniphila overview

| PRJNA36235 | ENA

Akkermansia muciniphila Membrane Protein Improves Cognitive Function in Aged Mice by Reducing IL-6 Expression

Project description:We implemented transcriptomic analyses of blood and hippocampus of old mice treated with Akkermansia muciniphila Membrane Protein for 8 weeks.

2023-08-25 | GSE162123 | GEO

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA921972 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA1145077 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Raw sequence reads

| PRJNA727952 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Raw sequence reads