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SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis

ABSTRACT: SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis

PROVIDER: PRJNA1006642 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25685449_1.fastq.gz	Fastqsanger.gz
	SRR25685449_2.fastq.gz	Fastqsanger.gz
	SRR25685450_1.fastq.gz	Fastqsanger.gz
	SRR25685450_2.fastq.gz	Fastqsanger.gz
	SRR25685451_1.fastq.gz	Fastqsanger.gz

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SUMOylation fine tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis

Project description:Reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine tuning the transcriptional activity of HEY1. Specifically, S UMOylation facilitates the formation of the HEY1 transcriptional complex and enhances its DNA binding capability in endothelial cells.

2023-08-18 | PXD044611 |

SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [HEY1 ChIP-seq]

Project description:SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [HEY1 ChIP-seq]

| PRJNA1006648 | ENA

SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [HUVEC RNA-seq]

Project description:Previous studies have shown that HEY1 is a major downstream transducer of NOTCH signaling and transcriptionally represses VEGFR2. We aimed to investigate whether SUMOylation is critical for HEY1-mediated transcriptional regulation of angiogenesis in endothelial cells. To address this question, we performed RNA-seq to assess the repressive landscape of HEY1-WT and HEY1-3KR.

2024-01-10 | GSE241150 | GEO

SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [MLEC RNA-seq]

Project description:To validate the results in primary endothelial cells including HUVECs and HMVECs, the effect of HEY1 SUMOylation on angiogenic functions was examined in MLECs isolated form Hey1 iEC-KO HEY1-WT/3KR iEC-KI mice.

2024-01-10 | GSE241151 | GEO

SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [HEY1 ChIP-seq]

Project description:Our previous results from RNA-seq and IP-MS together suggest that SUMOylation may be critical for the DNA-binding capability of HEY1 to enhance its transcriptional repressive activity. To confirm our speculation, we conducted ChIP assays in HUVECs.

2024-01-10 | GSE241148 | GEO

SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [MLEC RNA-seq]

Project description:SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [MLEC RNA-seq]

| PRJNA1006649 | ENA

SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [HUVEC RNA-seq]

Project description:SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis [HUVEC RNA-seq]

| PRJNA1006647 | ENA

Yeast ORC sumoylation status fine-tunes origin activity

Project description:Sumoylation is emerging as a post-translation modification important for chromosome duplication and stability. The origin recognition complex (ORC), which directs DNA replication initiation by loading the MCM replicative helicases onto origins, is sumoylated in both yeast and human cells. However, the biological consequences of ORC sumoylation are largely unclear. Here we report the effects of hyper- and hypo-sumoylation of yeast ORC using multiple approaches. We show that ORC hyper-sumoylation preferentially reduces the activity of a subset of early origins, while Orc2 hypo-sumoylation has an opposing effect. Mechanistically, ORC hyper-sumoylation leads to reduced MCM loading in vitro and diminished MCM chromatin association in vivo. The importance of an appropriate level of ORC sumoylation is suggested by the data that either hyper- or hypo-sumoylation of ORC results in genome instability and a dependence on other genome maintenance factors for cell fitness. Thus, yeast ORC sumoylation status needs to be fine-tuned to achieve optimal origin activity control and genome stability.

2023-03-11 | PXD032977 | Pride

SUMOylation fine-tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-10 | GSE241152 | GEO

Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity

Project description:Post-translational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is mostly unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylation of NFATc1 represses IL-2 in vitro, but its role in T cell-mediated immune responses in vivo is not clear. To this end, we generated a novel Nfatc1 transgenic mouse, which prevents SUMO modification of NFATc1. Avoidance of NFATc1 SUMOylation ameliorated experimental autoimmune encephalomyelitis as well as graft-versus-host disease. An elevated IL-2 production promoted Treg expansion and suppressed autoreactive or alloreactive T cells. Mechanistically, increased IL-2 secretion counteracted IL-17 and IFN-γ expression through STAT5 and Blimp-1 induction. Then, Blimp-1 repressed IL-2 itself and the as well induced, proliferation-associated survival factor Bcl2A1. Collectively, we demonstrate that prevention of NFATc1 SUMOylation fine-tunes T-cell responses towards lasting tolerance. Thus, targeting NFATc1 SUMOylation presents a novel and promising strategy to treat T cell-mediated inflammatory diseases.

2020-07-01 | GSE148087 | GEO

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