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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Directional RNA-Seq]

ABSTRACT: Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Directional RNA-Seq]

PROVIDER: PRJNA1009071 | ENA |

REPOSITORIES: ENA

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus

Project description:Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [HiChIP]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [ChIP-Seq]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Capture Hi-C]

Project description:Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Capture Hi-C]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Directional RNA-Seq]

Project description:In this study we combined epigenetic, transcriptional and recombinational assays of wild type and mutated Igh alleles to uncover structure function relationships between sequences that configure the locus for the first step of gene assembly.

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus

Project description:This SuperSeries is composed of the SubSeries listed below.

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [HiChIP]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [ChIP-Seq]

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Multimodal multiscale analysis reveals flexible DNA contacts of bacterial nucleoprotein filaments

Project description:Gene silencing in bacteria is mediated by chromatin proteins, of which Escherichia coli H-NS is a paradigmatic example. H-NS forms nucleoprotein filaments with either one or two DNA duplexes. However, the overall structures, arrangements of DNA-binding domains (DBDs), positions of DBD–DNA contacts, and determinants of genomic distribution for these linear and bridged filaments are uncertain. To connect H-NS structures that silence genes in vivo with features elucidated in vitro, we developed a multimodal multiscale analysis that combines a new method for chromatin reconstitution and mapping (Nitro-seq), ChIP-seq, tethered-nuclease mapping of DBD–DNA contacts (TEN-map), ·OH footprinting, molecular dynamics, and bioinformatics. We find that DNA sequence principally governs H-NS-filament location with indistinguishable sequence specificity in bridged or linear forms with or without the H-NS modifiers StpA and Hha and that DBD–DNA contacts vary in orientation and position with ~10-bp average spacing. Our results support a hemi-sequestration model of linear-to-bridged filament switching.

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