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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [ChIP-Seq]

ABSTRACT: Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [ChIP-Seq]

PROVIDER: PRJNA1009088 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25757828.fastq.gz	Fastqsanger.gz
	SRR25757829.fastq.gz	Fastqsanger.gz
	SRR25757830.fastq.gz	Fastqsanger.gz
	SRR25757831.fastq.gz	Fastqsanger.gz
	SRR25757832.fastq.gz	Fastqsanger.gz

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [HiChIP]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Capture Hi-C]

Project description:Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Capture Hi-C]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Directional RNA-Seq]

Project description:Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Directional RNA-Seq]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [HiChIP]

Project description:In this study we combined epigenetic, transcriptional and recombinational assays of wild type and mutated Igh alleles to uncover structure function relationships between sequences that configure the locus for the first step of gene assembly.

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [ChIP-Seq]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Directional RNA-Seq]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus [Capture Hi-C]

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Coordination between transcriptional orientation and nucleoprotein complexes generate chromatin configuration of IgH locus

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-22 | GSE241741 | GEO

5C Chromatin interactions in the Igh locus in resting splenic B cells

Project description:These tracks include chromatin interaction data produced using the 5C (chromatin conformation capture carbon copy) method by the Kenter Lab located at the University of Illinois College of Medicine, Chicago, IL. These tracks show looping interactions across the Igh locus using alternating forward and reverse primer design scheme. The 3C method uses formaldehyde crosslinking to covalently associate interacting chromatin segments in intact cells. The cells are then lysed and chromatin is digested with the Hind III restriction enzyme. The digested fragments are ligated under dilute conditions to promote intra-molecular ligation. A genome-wide interaction library of ligation products corresponding to all possible chromatin interactions is produced by this method. In 5C assays, over 12,000 potential ligation products specific to the Igh locus are detected by PCR using multiplexed primer pairs. Here we focused on the 3’ end of the Igh locus to evaluate the status of the constant region domain of the locus in LPS+IL4 activated splenic B cells. We observe that the configuration of the 3’ end of the Igh locus spanning the CH region genes assumes a developmental stage specific configuration in B lineage B cells. We find that the interaction frequency and activation state of the 3’ enhancer increases as B cells mature.

2021-11-23 | GSE183574 | GEO

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