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MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth

ABSTRACT: MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth

PROVIDER: PRJNA1011806 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25867532.fastq.gz	Fastqsanger.gz
	SRR25867533.fastq.gz	Fastqsanger.gz
	SRR25867534.fastq.gz	Fastqsanger.gz
	SRR25867535.fastq.gz	Fastqsanger.gz
	SRR25867536.fastq.gz	Fastqsanger.gz

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MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth

Project description:Depletion of Mcpip1 in the cells of myeloid origin modifies the sensitivity to the cutaneous chemical carcinogenesis. It attenuates epidermal proliferation and increases the susceptibility to the formation of melanocytic nevi. Thus, myeloid Mcpip1 is an important modulator in the course of skin carcinogenesis.

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Distinct roles of keratinocyte- and myeloid- MCPIP1 in maintaining skin homeostasis

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Project description:Obesity is considered a serious chronic disease, which is associated with increased risk of developing cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes. Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1), also called Regnase-1, is an RNase that decreases stability of transcripts coding for inflammation-related proteins. In addition, MCPIP1 plays an important role in the regulation of adipogenesis in vitro by reducing the expression of key transcription factors, including C/EBPβ and PPARγ, during adipocyte differentiation. Here we present RNA-Seq and proteomic analysis of 3T3-L1 adipocytes overexpressing wild-type MCPIP1 (WTMCPIP1) and mutant MCPIP1 (D141NMCPIP1) at day 2 and 4 of differentiation, respectively. RNA-Seq analysis followed by confirmatory Q-RT-PCR revealed that elevated MCPIP1 levels in 3T3-L1 adipocytes upregulated transcripts encoding proteins involved in signal transmission and cellular remodeling and downregulated transcripts of factors involved in metabolism. These data are consistent with our LC-MS/MS analysis, which showed that MCPIP1 expressing adipocytes exhibit upregulation of proteins involved in cellular organization and movement and decreased levels of proteins involved in lipid and carbohydrate metabolism. Moreover, MCPIP1 adipocytes are characterized by decreased Glut4 levels and impaired glucose uptake. Overall, our ﬁndings demonstrate that MCPIP1 is an important regulator of adipogenesis and adipocyte metabolism.

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