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Gene expression profile of submandibular gland from IgG4 related disease patients at a single cell level.

ABSTRACT: Gene expression profile of submandibular gland from IgG4 related disease patients at a single cell level.

PROVIDER: PRJNA1014495 | ENA |

REPOSITORIES: ENA

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Gene expression profile of submandibular gland from IgG4 related disease patients at a single cell level.

Project description:IgG4-related disease (IgG4-RD) is an autoimmune disease with an unknown etiology. In this study, we focused on non-hematopoietic cells in the submandibular gland of IgG4-RD patients. Through single-cell RNA sequencing, our aim was to unravel the contributions of these cells to the development and progression of IgG4-RD.

2024-02-19 | GSE242778 | GEO

Gene expression of CD4+CD8+ Tfh cells in lesions of IgG4-related disease and CD4+CD8+ Tfh in tonsil.

Project description:To further know features of CD4+CD8+ Double positive (DP)-Tfh cells in respective lymphoid tissues, we subsequently investigated transcriptomes of DP-Tfh cells in submandibular gland lesions of IgG4-RD in comparison to those of DP-Tfh cells in tonsils. Results showed that DP-Tfh cells of IgG4-RD lesions were more apt to present CTL-related genes such as Eomes and granzymes than DP-Tfh cells in tonsils. It was also noted that the level of CD70 in DP-Tfh cells of IgG4-RD lesions was higher than that of tonsillar DP-Tfh cells. Genes related to Tfh cell function were seemed to be presented in DP-Tfh cells of tonsils compared to DP-Tfh cells of IgG4-RD lesions.

2022-08-10 | GSE202617 | GEO

Gene expression profiles for murine submandibular gland stem cells

Project description:To compare the gene expression profile of submandibular gland stem cells to submandibular gland epithelia, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the differential expression in the stem cells and the non-stem cell epithelia. Murine submandibular gland stem cells and non-stem cell epithelia are sorted through FACS

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Gene expression profile of murine submandibular gland epithelial cells

Project description:We examined effects of aging on gene expression profile of murine submandibular gland epithelial cells

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Gene expression profiles for murine submandibular gland stem cells

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Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

Project description:In order to explore the functions of carbonic anhydrase VI (CAVI) more fully, we examined the transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6-/- mice by cDNA microarray. 94, 56, and 127 genes were up- or down-regulated in the above-mentioned tissues of Car6-/- mice, respectively. The functional clustering of differentially expressed genes revealed a number of altered biological processes. In the duodenum, the significantly affected biological pathways included immune system process and retinol metabolic process. Response to oxidative stress and brown fat cell differentiation changed remarkably in the submandibular gland. Notably, the submandibular gland, stomach, and duodenum shared one prominent transcriptional susceptibility pathway-catabolic process. Submandibular gland, stomach, and duodenum samples were collected from three wild-type and three Car6-/- female mice, respectively, at the age of two months. Total RNAs were purified and used for cDNA microarray.

2010-10-02 | E-GEOD-20423 | biostudies-arrayexpress

Genome-wide expression analysis of submandibular salivary gland tumours of Smgb-Tag mice

Project description:To reveal novel molecular factors behind the development of salivary gland cancer, we performed gene expression analyses from Smgb-Tag mouse salivary gland samples. The overall purpose was to apply these results for clinical use to find new approaches for both possible therapeutic targets and more accurate diagnostic tools in identification of salivary gland cancers. Smgb-Tag mouse strain, in which salivary neoplasms arise through a dysplastic phase in submandibular glands, was investigated using genome-wide microarray expression analysis, Ingenuity pathway analysis, RT-PCR, and immunohistochemistry. 3 normal, 3 dysplastic, and 3 adenocarcinomatous submandibular gland tumours of Smgb-Tag mice.

2014-09-30 | E-GEOD-61868 | biostudies-arrayexpress

Adult parotid gland RNA-seq libraries, and embryonic submandibular gland RNA-seq libraries

Project description:Adult parotid gland RNA-seq libraries and embryonic submandibular gland RNA-seq libraries were created to examine the mRNA species present in these secretory glands, as part of a project to understand acinar glands in general.

2017-08-18 | GSE102788 | GEO

Gene expression profile of murine submandibular gland epithelial cells

Project description:Gene expression profile of murine submandibular gland epithelial cells

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Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

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