Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [scRNA-Seq]

ABSTRACT: Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [scRNA-Seq]

PROVIDER: PRJNA1024481 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26292789.fastq.gz	Fastqsanger.gz
	SRR26292790.fastq.gz	Fastqsanger.gz
	SRR26292791.fastq.gz	Fastqsanger.gz
	SRR26292792.fastq.gz	Fastqsanger.gz
	SRR26292793.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas

Project description:Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas

| PRJNA1024477 | ENA

Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [bulkRNA-Seq]

Project description:Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [bulkRNA-Seq]

| PRJNA1024482 | ENA

Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [scRNA-Seq]

Project description:The perinatal period is a critical time-window in establishing T-cell tolerance. Regulatory T cells (Tregs) made during the first two weeks of life are key drivers of perinatal tolerance induction, but how these cells are generated and operate has not been established. To elucidate the unique environment murine perinatal Tregs encounter within the lymph nodes (LNs) as they first emerge from the thymus, and how it evolves over the succeeding days, we employed single-cell RNA sequencing to generate an atlas of the early LN niche. A highly dynamic picture emerged, the stromal-cell compartment showing the most striking changes and putative interactions with other LN cell compartments. In particular, LN stromal cells showed increasing potential for lymphocyte interactions with age. Analogous studies on mice lacking α:β T cells or enriched for autoreactive α:β T cells revealed an acute stromal-cell response to α:β T cell dysfunction, largely reflecting dysregulation of Tregs. Punctual ablation of perinatal Tregs induced stromal-cell activation that was dependent on both interferon-gamma signaling and activation of conventional CD4+ T cells. These findings elucidate some of the earliest cellular and molecular events in perinatal induction of T-cell tolerance, providing a framework for future explorations.

2023-12-27 | GSE244742 | GEO

Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [bulkRNA-Seq]

2023-12-27 | GSE244741 | GEO

Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-27 | GSE244743 | GEO

Lymph node myeloid cells

Project description:Lymph node myeloid cells

| PRJNA895429 | ENA

Comparison of lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC)

Project description:A classifier was build on 82 training samples to differentiate between lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC). The 102 predictor genes that resulted from this classifier where then validated against a independent validation set.

2005-01-09 | E-UMCU-11 | biostudies-arrayexpress

Matrix Remodelling during Lymph Node Expansion

Project description:In this study we focussed our investigations on ECM remodelling by FRCs during lymph node (LN) expansion, and the interconnection between the cellular and ECM components of the conduit network. We demonstrate a loss of ECM components of the conduit during acute LN expansion

2021-05-11 | PXD015816 | Pride

Single-cell sequencing reveals cancer cell heterogeneity in a murine breast cancer lymph node metastasis model

Project description:Using a mouse model of breast cancer that develops spontaneous lymph node metastasis, we performed high-resolution single-cell RNA sequencing (scRNA-Seq) of the primary tumor and TDLN to measure how cancer cells adapt to the dynamic lymph node microenvironment. To understand the dynamic change of lymph node microenvironment after cancer cell invasion, we also compared the gene-expression alteration between naive lymph node and TDLN at single-cell level.

2023-06-14 | GSE168181 | GEO

Familial Blood and Lymph Node Cancers

Project description:Familial Blood and Lymph Node Cancers

| PRJNA344002 | ENA