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Topoisomerase I (TOP1) is a functional mitotic interactor of the bookmarking factor HNF1B [ChIPseq_KEC]

ABSTRACT: Topoisomerase I (TOP1) is a functional mitotic interactor of the bookmarking factor HNF1B [ChIPseq_KEC]

PROVIDER: PRJNA1026898 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26350800_1.fastq.gz	Fastqsanger.gz
	SRR26350800_2.fastq.gz	Fastqsanger.gz
	SRR26350900_1.fastq.gz	Fastqsanger.gz
	SRR26350900_2.fastq.gz	Fastqsanger.gz
	SRR26350801_1.fastq.gz	Fastqsanger.gz

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Topoisomerase I (TOP1) is a functional mitotic interactor of the bookmarking factor HNF1B

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Topoisomerase I (TOP1) is a functional mitotic interactor of the bookmarking factor HNF1B

Project description:HNF1B (Hepatocyte Nuclear Factor 1-Beta) is a POU-homeobox transcription factor expressed in kidney and frequently mutated in patients suffering from Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT). HNF1B is a bookmarking factor, able to bind mitotic chromatin and necessary for the post-mitotic reactivation of gene expression. In order to characterize the molecular functions of HNF1B as a bookmarking factor, we performed ChIPseq on asynchronous and mitotic renal cells. We developed a novel ChIP method with a non-aqueous crosslinking (NAQC) to circumvent the well-known artefactual effects of formaldehyde crosslinking of mitotic chromosomes. NAQC-ChIP allowed the retention of the mitotic signal that was lost with a regular ChIP. With this novel methodology, we show that the vast majority HNF1B binding sites detected in asynchronous cells are also bound in mitosis.

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Topoisomerase I (TOP1) is a functional mitotic interactor of the bookmarking factor HNF1B [ChIPseq_KEC]

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