Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Regulation of muscle mass by Thrombospondin-1

ABSTRACT: Regulation of muscle mass by Thrombospondin-1

PROVIDER: PRJNA1029530 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26419411.fastq.gz	Fastqsanger.gz
	SRR26419412.fastq.gz	Fastqsanger.gz
	SRR26419413.fastq.gz	Fastqsanger.gz
	SRR26419414.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Regulation of muscle mass by Thrombospondin-1

Project description:Loss of muscle mass is a pathological driver in both chronic illness and aging. We have discovered that skeletal muscle specific thrombospondin-1 (Thbs1) transgenic mice have profound muscle atrophy with age-dependent decreases in exercise capacity and premature lethality. Here, we compared the transcriptional profiles of skeletal muscle from control non-transgenic mice with those overexpressing Thbs1 in order to elucidate the transcriptional changes underlying the observed effects on skeletal muscle mass. The overall purpose was to identify new, effective targets to combat muscle atrophy and sarcopenia.

2024-04-18 | GSE245663 | GEO

mRNA degradome analysis indicating miRNA regulation in muscle mass development

Project description:mRNA degradome analysis indicating miRNA regulation in muscle mass development

| PRJNA532438 | ENA

Role of the Muscle-Brain-Gut axis in the regulation of skeletal muscle mass

Project description:Role of the Muscle-Brain-Gut axis in the regulation of skeletal muscle mass

| PRJNA1048525 | ENA

mRNA degradome analysis indicating miRNA regulation in muscle mass development

Project description:The search of the molecular process associated with development and metabolism of muscle mass is still actual, what in humans is related to muscle modification after endurance training exercises. In turn in farm animals, the high meat content in carcasses delivers higher economic benefit. Over a few recent years, scientists using next-generation-sequencing (NGS) methods attempted to indicate proteins/genes engaged in muscle mass development. The aim of the present study was to show mRNA degradome signals that could be characteristic for molecular processes associated with muscle development in pigs and indicate the miRNA regulation controlling this process based using also NGS technology. The preliminary results exhibited that the huge amount of miRNAs regulate gene expression at the different molecular level than mRNA degradation. Moreover, the study found significant differences between investigated pig breeds. The results often were opposite for Pietrain breed that could be related to differences in muscle fibre composition and their microstructure. The present study showed an interesting dependence between miRNA and their targets - the most of transcripts found as being degraded, were associated with controlling muscle mass development such as ENO3, CKM, CRYAB and ADAM19. In turn, performed PAREsnip analysis showed that only a small percentage of identified degraded transcripts was associated with miRNA regulation, what suggested a different mechanism of mRNA degradation. Nevertheless, the complete view of miRNA regulation could be obtained in the more advanced study, which would employ miRNA transfection procedure in muscle tissue cell culture that could be a subject of further research.

2019-04-12 | GSE129681 | GEO

Effect of an Oral Nutritional Supplement on Muscle Mass During Anticancer Treatment

Project description:Malnutrition and low muscle mass (sarcopenia) are common problems in patients with cancer. However, a low muscle mass is associated with negative clinical outcomes in patients with cancer. Therefore, it is very important to maintain muscle mass in this population. This study aims to investigate the effect of an oral nutritional supplement on skeletal muscle mass during anti-cancer treatment.

| 2256 | ecrin-mdr-crc

Role of the Muscle-Brain-Gut axis in the regulation of skeletal muscle mass II

Project description:Role of the Muscle-Brain-Gut axis in the regulation of skeletal muscle mass II

| PRJNA1049427 | ENA

Role of the Muscle-Brain-Gut axis in the regulation of skeletal muscle mass

Project description:We propose that the Muscle-Brain-Gut axis regulates skeletal muscle mass through the defined mechanism.

2023-12-11 | GSE249324 | GEO

Role of the Muscle-Brain-Gut axis in the regulation of skeletal muscle mass II

Project description:We propose that the Muscle-Brain-Gut axis regulates skeletal muscle mass through the defined mechanism.

2023-12-13 | GSE249515 | GEO

FBXW7 coordinates postprandial muscle glucose metabolism and maintenance of skeletal muscle mass

Project description:In this study, we show that muscle-specific inactivation of FBXW7 elicits striking defects in postprandial glucose metabolism and failure to maintain skeletal muscle mass in adult mice. Further, mice lacking FBXW7 exhibited impaired endurance capacity and exacerbated HFD-induced insulin resistance and postprandial hyperglycemia. At the mechanistic level, RNAseq and quantitative proteomic analysis revealed global effects of FBXW7 deficiency on skeletal muscle transcriptome and proteome. This work illustrates a prominent role of FBXW7 in integrating postprandial nutritional signals to coordinate glucose metabolism and muscle mass maintenance.

2024-06-21 | GSE140503 | GEO

FBXW7 coordinates postprandial muscle glucose metabolism and maintenance of skeletal muscle mass

Project description:FBXW7 coordinates postprandial muscle glucose metabolism and maintenance of skeletal muscle mass

| PRJNA589977 | ENA