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The differential expression of tRF&tiRNA in eutopic and ectopic endometrial tissue of patients with ovarian endometriosis.

ABSTRACT: The differential expression of tRF&tiRNA in eutopic and ectopic endometrial tissue of patients with ovarian endometriosis.

PROVIDER: PRJNA1032016 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26515972.fastq.gz	Fastqsanger.gz
	SRR26515973.fastq.gz	Fastqsanger.gz
	SRR26515974.fastq.gz	Fastqsanger.gz
	SRR26515975.fastq.gz	Fastqsanger.gz
	SRR26515976.fastq.gz	Fastqsanger.gz

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The differential expression of tRF&tiRNA in eutopic and ectopic endometrial tissue of patients with ovarian endometriosis.

Project description:Endometriosis is a chronic gynecological disease that afflicts millions of women of reproductive age and has traditionally been diagnosed by laparoscopic surgery. This diagnostic barrier delays identification and treatment by years, resulting in prolonged pain and disease progression. Development of a noninvasive diagnostic test could significantly improve timely disease detection. We characterized eutopic and ectopic endometrium from five patients with ovarian endometriosis using tRF&tiRNA sequencing. We identified 294 tsRNAs by RNA microarray technique in eutopic and ectopic endometrium. Under the criteria of |log2FoldChange >2.0| and p-value < 0.05, 11 tRFs/tiRNAs were reported to be dysregulated in ectopic endometrial tissue compared with eutopic endometrial tissue, of which eight were up-regulated, and three were down-regulated.

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microRNA expression profilings in ectopic and eutopic endometria of ovarian endometriosis.

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