Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

NIH RECOVER: A Multi-site Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults

ABSTRACT: NIH RECOVER: A Multi-site Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults

PROVIDER: PRJNA1034229 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

NIH RECOVER: A Multi-site Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults

Project description:NIH RECOVER: A Multi-site Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults

| PRJNA1034230 | ENA

NIH RECOVER-Pediatric: Understanding the long-term impact of COVID on children and families

Project description:NIH RECOVER-Pediatric: Understanding the long-term impact of COVID on children and families

| PRJNA1033713 | ENA

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Project description:Post-acute sequelae of SARS-CoV-2 infection are debilitating, clinically heterogeneous, and of unknown molecular etiology. A transcriptome-wide investigation was performed in acutely infected patients followed clinically into the post-acute period. Distinct gene-expression signatures of post-acute sequelae were already present in whole-blood during acute infection, with innate and adaptive immune cells implicated in different symptoms. Two clusters of sequelae exhibited divergent plasma-cell associated gene-expression patterns. In one cluster, sequelae associated with higher expression of immunoglobulin-related genes in an anti-spike antibody titer-dependent manner. In the other, sequelae associated independently of these titers with lower expression of immunoglobulin-related genes, indicating lower non-specific antibody production in subjects with these sequelae. This relationship between lower total immunoglobulins and sequelae was validated in an external cohort. Altogether, multiple etiologies of post-acute sequelae were already detectable during SARS-CoV-2 infection, directly linking these sequelae with the acute host response to the virus and providing early insights into their development.

2022-12-06 | GSE215865 | GEO

Exophiala dermatitidis NIH/UT8656

Project description:Exophiala dermatitidis NIH/UT8656

| PRJNA49711 | ENA

Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses

Project description:This SuperSeries is composed of the following subset Series: GSE36241: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq) GSE37051: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression) Refer to individual Series

2012-09-19 | E-GEOD-37052 | biostudies-arrayexpress

The NIH Human Pluripotent Stem Cell Database

Project description:This SuperSeries is composed of the following subset Series: GSE32923: The NIH Human Pluripotent Stem Cell Database (Agilent, mRNA) GSE33789: The NIH Human Pluripotent Stem Cell Database (Affymetrix, mRNA) GSE34199: The NIH Human Pluripotent Stem Cell Database (Agilent, miRNA) GSE34869: The NIH Human Pluripotent Stem Cell Database (Illumina, methylation) GSE35157: The NIH Human Pluripotent Stem Cell Database (Illumina, snp) GSE35735: The NIH Human Pluripotent Stem Cell Database (Agilent, cgh) Refer to individual Series

2012-10-31 | E-GEOD-34200 | biostudies-arrayexpress

NIH 3T3: Ctrl vs Reo

Project description:Transcriptional profiling of NIH 3T3 comparing WT, RIG-I KD with and without reovirus infection

2020-10-07 | GSE127850 | GEO

NIA/NIH AGEMAP Brain Regions

Project description:NIA/NIH AGEMAP Brain Regions

| PRJNA101483 | ENA

NIH 3T3: Ctrl vs Reo

Project description:NIH 3T3: Ctrl vs Reo

| PRJNA525645 | ENA

NIA/NIH AGEMAP Multiple Tissues

Project description:NIA/NIH AGEMAP Multiple Tissues