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Single-nucleus transcriptomic sequencing of aging hypothalamus treated with 17a-estradiol

ABSTRACT: Single-nucleus transcriptomic sequencing of aging hypothalamus treated with 17a-estradiol

PROVIDER: PRJNA1043710 | ENA |

REPOSITORIES: ENA

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Single-nucleus transcriptomic sequencing of aging hypothalamus treated with 17a-estradiol

Project description:To dissect the role of 17a-estradiol in lifespan extending and its potential side effects for long-term administration, the pooled hypothalami from aging male Norway brown rats treated with 17a-estradiol for 6 months (O.T), aged male control (O), and young male control (Y) were subjected to single-nucleus transcriptomic sequencing (snRNA-seq).

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Estradiol and ICI 182,780 infusions induce similar transcriptomic response in late gestation fetal hypothalamus

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Single cell analysis of the aging hypothalamus

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