Project description:Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset cerebellar ataxia caused by mutations in SACS, which encodes the protein sacsin. Cellular ARSACS phenotypes include mitochondrial dysfunction, intermediate filament disorganization, and the progressive death of cerebellar Purkinje neurons. It is unclear how the loss of sacsin function causes these deficits, or why they manifest as cerebellar ataxia. To investigate this, we performed multi-omic profiling of sacsin knockout cells and compared them to wild-type controls
Project description:A temporal multi-omic analysis of Y. pestis and Y. pseudotuberculosis at physiologically relevant temperatures was performed to gain insights into how an acute and highly lethal bacterial pathogen, Y. pestis, differs from its less virulent progenitor, Y. pseudotuberculosis. Associated transcriptomics data have been deposited in GEO under accession number GSE30634.
