Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiles of complete hydatidiform moles and XBP1-overexpressing cell lines associated with progression to gestational trophoblastic tumors

ABSTRACT: Gene expression profiles of complete hydatidiform moles and XBP1-overexpressing cell lines associated with progression to gestational trophoblastic tumors

PROVIDER: PRJNA1063206 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptome analysis for XBP1 overexpressing complete hydatidiform mole-derived cell lines

Project description:The trophoblastic disease is a general term for diseases that cause abnormal growth of trophoblasts, the most frequent form of which is called hydatidiform mole (CHM). CHM cell lines (Hmol1-3B and Hmol1-2C) were established in our laboratory (Yamamoto E, et al. Int J Mol Med. 2017 Sep; 40(3): 614–622). In this study, XBP1 was overexpressed, and RNA sequencing was performed to investigate the role of XBP1 in CHM.

2024-12-21 | GSE252905 | GEO

The gene expression profiles of complete hydatidiform mole which developed post molar gestational trophoblast neoplasia

Project description:A complete hydatidiform mole (CHM) is a common disease known to develop post-molar gestational trophoblast neoplasia (GTN). However, the details of the molecular biological mechanisms underlying the progression to post-molar GTN from hydatidiform moles are still largely unknown. In this study, we performed RNA sequencing (RNA-seq) using archival fresh frozen tissues of patients with CHM and compared the gene expression profiles of patients who achieved spontaneous remission and those who developed post-molar GTN after the evacuation.

2024-12-21 | GSE252906 | GEO

Methotrexate resistant cell lines for the study of gestational trophoblastic neoplasia

Project description:The term gestational trophoblastic disease (GTD) describes a range of pathologies derived from the villous trophoblasts of the placenta. These include benign entities such as partial and complete hydatidiform mole as well as invasive cancers such as gestational choriocarcinoma, placental site trophoblastic tumors, and epithelioid trophoblastic tumors. Collectively, the malignant forms of GTD are known as gestational trophoblastic neoplasia (GTN). The risk of GTN following a complete molar pregnancy ranges between 8-25%. Low risk patients are expected to have a high likelihood of response to single agent chemotherapy with methotrexate or actinomycin D, but the incidence of resistance to single agent chemotherapy among low risk patients remains 25-50%. We used gene expression microarrays to compare methotrexate sensitive trophoblastic cell lines to sublines that were conditioned to become methotrexate resistant.

2017-03-03 | GSE88873 | GEO

Definitive SNP/CNV haplotype map of Asians determined using a collection of complete hydatidiform moles

Project description:This SuperSeries is composed of the following subset Series: GSE18642: Definitive SNP/CNV haplotype map of Asians determined using a collection of complete hydatidiform moles (Affymetrix) GSE18663: Definitive SNP/CNV haplotype map of Asians determined using a collection of complete hydatidiform moles (Illumina) Refer to individual Series

2010-05-17 | E-GEOD-18701 | biostudies-arrayexpress

Copy number analysis of Gestational Trophoblastic Disease

Project description:Purpose was to determine whether varying gestational trophoblastic disease samples carry common copy number changes.

2021-04-14 | E-MTAB-10303 | biostudies-arrayexpress

RNA-Seq analysis of Gestational Trophoblastic Diseases

Project description:Purpose was to determine whether varying gestational trophoblastic disease samples exhibit differences in RNA expression and fusion transcripts.

2021-04-14 | E-MTAB-10321 | biostudies-arrayexpress

Transcriptome analysis for XBP1 overexpressing complete hydatidiform mole-derived cell lines

Project description:Transcriptome analysis for XBP1 overexpressing complete hydatidiform mole-derived cell lines

| PRJNA1063209 | ENA

Methylation profiling of hydatidiform moles

Project description:Methylation profiling of hydatidiform moles

| PRJNA279849 | ENA

Gene exprssion profile of gestational trophoblastic neoplasms

Project description:Gene exprssion profile of gestational trophoblastic neoplasms

| PRJNA559869 | ENA

RNA-Seq analysis of Gestational Trophoblastic Diseases

Project description:RNA-Seq analysis of Gestational Trophoblastic Diseases