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The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

ABSTRACT: The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

PROVIDER: PRJNA1066336 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27608481_1.fastq.gz	Fastqsanger.gz
	SRR27608481_2.fastq.gz	Fastqsanger.gz
	SRR27608482_1.fastq.gz	Fastqsanger.gz
	SRR27608482_2.fastq.gz	Fastqsanger.gz
	SRR27608483_1.fastq.gz	Fastqsanger.gz

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The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

Project description:Background. Prenatal exposure to nicotine has been documented to impose numerous deleterious effects on fetal development. However, the epigenetic changes promoted by nicotine exposure on germ cell are still not well understood. Objectives. In this study, we focused on elucidating the impact of prenatal nicotine exposure on regulatory epigenetic mechanisms important for the germ cells development. s important for the germ cells development

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The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [RNA-seq]

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The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat

Project description:The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat

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The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [RNA-seq]

Project description:The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [RNA-seq]

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Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats

Project description:Here, we investigated whether prenatal exposure to nicotine alters kidney glomerular mass and genome-wide gene expression profiles in two genetically distant strains of rats, namely spontaneously hypertensive rats (SHR) and Brown Norway (BN) rats. Nicotine or saline were administered to BN and SHR dams via osmotic pumps throughout gestation. Kidneys from 9-week-old male offspring were studied. Equal amounts of RNA from individual animals were pooled within each of the four experimental groups SHR (nicotine: n=13; saline: n=12) and BN (nicotine: n=12; saline: n=12) and hybridized with the Rat RAE-230a GeneChip (Affymetrix).

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Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats

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Gestational food-restriction but not nicotine exposure regulates gene expression in the striatum of adolescent rats

Project description:We used microarrays to determine the effect of prenatal nicotine exposure on gene expression profiles in the striatum of adolescent rats. We found a number of immediate early genes to be differentially expressed due to food-restriction. We compared control (n=8), nicotine exposed (n=7) and a group of animals matched to the food intake of nicotine exposed animals (n=10) to identify gene expression changes associated with prenatal nicotine exposure

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Chronic nicotine exposure (kuo-affy-human-232930)

Project description:The long-term goal of this project is to establish whether and how chronic nicotine exposure affects nervous system function. The biological targets of nicotine action are diverse members of the superfamily of neurotransmitter-gated ion channels called nicotinic acetylcholine receptors (nAChR). nAChR play multiple, critical roles in chemical signaling throughout the brain and body. They also must be involved in nicotine dependence, which drives tobacco product use responsible for tremendous economic and personal costs. To define changes in gene expression induced by nicotine exposure in a model neuronal cell lines expressing at least two nicotinic receptor subtypes. Nicotine exposure exerst at least some of its effects on nervous system function by altering gene expression. Cells of the SH-SY5Y human neuroblastoma will be exposed to an efficacious dose of nicotine or to control medium for two different periods. Keywords: time-course

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