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Chromatin conformation and histone modification profiling across human kidney anatomic regions [CUT&RUN]

ABSTRACT: Chromatin conformation and histone modification profiling across human kidney anatomic regions [CUT&RUN]

PROVIDER: PRJNA1066378 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27636700_1.fastq.gz	Fastqsanger.gz
	SRR27636700_2.fastq.gz	Fastqsanger.gz
	SRR27636701_1.fastq.gz	Fastqsanger.gz
	SRR27636701_2.fastq.gz	Fastqsanger.gz
	SRR27636702_1.fastq.gz	Fastqsanger.gz

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Chromatin conformation and histone modification profiling across human kidney anatomic regions [CUT&RUN]

Project description:Here, we leveraged our recently described high-yield nuclei extraction method and performed Hi-C and Cleavage Under Targets and Release Using Nuclease (CUT&RUN) sequencing of histone modifications (H3K4me3 and H3K27me3) in parallel on the kidney cortex, medulla and papilla samples dissected from the same donor. This site describes the CUT&RUN data.

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Chromatin conformation and histone modification profiling across human kidney anatomic regions

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Chromatin conformation and histone modification profiling across human kidney anatomic regions [Hi-C]

2024-06-20 | GSE253632 | GEO

Chromatin conformation and histone modification profiling across human kidney anatomic regions

Project description:This SuperSeries is composed of the SubSeries listed below.

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Epigenetic Switch Reshapes Epithelial Stem/Progenitor Cells Signatures and Contributes to Inflammatory Programming in Hidradenitis Suppurativa [CUT&RUN]

Project description:1) By using dual-omics profiling for both chromatin accessibility and gene expression as well as CUT&RUN sequencing for chromatin modification states, we identified that numerous disease-associated inflammatory enhancers were epigenetically activated and co-exist with the transcriptional states of their target genes in basal progenitor cells. 2) By using CUT&RUN sequencing , we identified numerous S100A8 binding DNA sequences in HS epidermal cells.

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Bulk Cut&run and Cut&tag

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