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Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow

ABSTRACT: Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow

PROVIDER: PRJNA1067567 | ENA |

REPOSITORIES: ENA

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Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow I

Project description:Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we define human BMPC heterogeneity and track the recruitment of antibody-secreting cells (ASC) from SARS-CoV-2 vaccine immune reactions to the bone marrow (BM). Trajectories based on single-cell transcriptomes and repertoires of peripheral and BM ASC reveal sequential colonisation of BMPC compartments. In activated B cells, IL-21 suppresses CD19 expression, indicating that CD19low-BMPC are derived from follicular, while CD19high-BMPC originate from extrafollicular immune reactions. In primary immune reactions, both CD19low- and CD19high-BMPC compartments are populated. In secondary immune reactions, most BMPC are recruited to CD19high-BMPC compartments, reflecting their origin from extrafollicular reactivations of memory B cells. A pattern also observed in vaccinated-convalescent individuals and upon diphtheria/tetanus/pertussis recall-vaccination. Thus, BMPC diversity reflects the evolution of a given humoral immune response.

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Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow II

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Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow II

Project description:Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow II

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Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow I

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Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow

Project description:This SuperSeries is composed of the SubSeries listed below.

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RNA sequencing analysis of mouse follicular B cells, memory B cells, plasmablasts and plasma cells

Project description:The purpose of this study was to compare relative mRNA transcript levels between mouse follicular B cells, memory B cells, plasmablasts and plasma cells.

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Cross-species Regulatory Network Analysis Identifies FOXO1 as a Driver of Ovarian Follicular Recruitment

Project description:To indentify the master regulators that control the processes between the pre-recruitment and pre-ovulatory F5 follicular stages in laying hens. RNA was isolated from a group of 3-5 pre-recruitment follicles and the most recently recruiteed pre-ovualtory follicle (F5). After RNA isolation, follicles underwent RNA sequencing and differential gene expression analysis occurred.

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Expression data from murine bone marrow-resident plasma cells and spleen mature follicular B cells

Project description:CD138+ B220- plasma cells were sorted from bone marrow and B220+ CD23+ mature follicular B cells were sorted from the spleens. Plasma cells were sorted from C57BL/6 mice 7 days after boosting with antigen, with mice first primed with an i.p. injection of KLH/IFA followed by boost at day 21 with KLH/PBS i.p. Mature B cells were sorted from antigen-naïve C57BL/6 mice. We compared expression profiles of plasma cells and mature B cells to identify differentially expressed transcripts. Seven days after boosting with KLH, plasma cells were enriched by CD138-PE/anti-PE magnetic bead enrichment and then sorted to purity. Affymetrix microarrays were performed on 50,000-70,000 plasma cells and 2,000,000-3,000,000 naïve B cells.

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