Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria

ABSTRACT: IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria

PROVIDER: PRJNA1068962 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27723107.fastq.gz	Fastqsanger.gz
	SRR27723108.fastq.gz	Fastqsanger.gz
	SRR27723109.fastq.gz	Fastqsanger.gz
	SRR27723110.fastq.gz	Fastqsanger.gz
	SRR27723111.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria

Project description:To investigate transciprtomic landscape changes of Gr-1+ cells after P/A immunization and NKT cells after anti-IL-27 antibody, we isolated Gr-1+ cells on day 1 and 3 after P/A immunization and NKT cells on day 3 after P/A immunization with anti-IL-27 antibody and isotype contorl. We then performed gene expression profiling analysis of RNA-seq data for Gr-1+ cells on day 0, 1, and 3 after P/A immunization and NKT cells on day 3 after P/A immunization with anti-IL-27 antibody and isotype control. (n=3 per group)

2024-02-07 | GSE254186 | GEO

Transcription profiling of mouse vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)

Project description:Analysis of in vivo antigen-specific (LCMV-specific, SMARTA TCR transgenic) follicular helper CD4 T cells (CXCR5high),versus non-follicular helper CD4 T cells (CXCR5low), eight days after viral infection. A paper including data analysis of these experiments has been accepted for publication (Robert J. Johnston et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of follicular helper CD4 T cell differentiation). Experiment Overall Design: Analysis of in vivo antigen-specific (LCMV-specific, SMARTA TCR transgenic) follicular helper CD4 T cells (CXCR5high), versus non-follicular helper CD4 T cells (CXCR5low), eight days after viral infection.

2009-08-07 | E-GEOD-16697 | biostudies-arrayexpress

A miR-23~27~24 regulon that controls follicular helper T cell differentiation

Project description:Follicular helper T (Tfh) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged as important players in regulating Tfh cell biology. Here, we show that loss of miR-23~27~24 clusters in T cells resulted in elevated Tfh cell frequencies upon different immune challenges whereas overexpression of this miRNA family led to reduced Tfh cell responses. Mechanistically, miR-23~27~24 clusters coordinately control Tfh cells through targeting a network of genes that are crucial for Tfh cell biology. Among them, thymocyte selection-associated HMG-box protein (TOX) was identified as a central transcription regulator in Tfh cell development. TOX is highly up-regulated in both mouse and human Tfh cells in a BCL6-dependent manner. In turn, TOX promotes the expression of multiple molecules that play critical roles in Tfh cell differentiation and function. Collectively, our study on miR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in orchestrating Tfh cell responses.

2019-08-21 | GSE118698 | GEO

Murine follicular helper T cells

Project description:Murine follicular helper T cells

| PRJNA830482 | ENA

A miR-23~27~24 regulon that controls follicular helper T cell differentiation

Project description:A miR-23~27~24 regulon that controls follicular helper T cell differentiation

| PRJNA486508 | ENA

Expression Data from in vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)

2009-07-28 | GSE16697 | GEO

Differential Expression of IL-2 Defines CD4 T cells fated for Follicular Helper and Non-follicular Helper Development (RNA-Seq)

Project description:IL-2 production defines precursors fated to become T Follicular Helper cells

2018-09-19 | GSE116607 | GEO

Differential Expression of IL-2 Defines CD4 T cells fated for Follicular Helper and Non-follicular Helper Development (ATAC-Seq)

Project description:IL-2 production defines precursors fated to become T Follicular Helper cells

2018-09-19 | GSE116606 | GEO

Transcription profiling of WT and NFAT2 KO follicular helper CD4 T cells and non follicular helper CD4 T cell populations

Project description:Comparatative gene expression analysis for wild type and NFAT2-/- CD4 T cell subsets including follicular helper CD4+ T (TFH) cells, activated CD4+ T cells, and naive CD4+ T cells isolated from the spleen.

2014-02-21 | E-MEXP-3820 | biostudies-arrayexpress

Mll1 in T follicular helper cell differentiation

Project description:Mll1 in T follicular helper cell differentiation

| PRJNA939741 | ENA