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A miR-23~27~24 regulon that controls follicular helper T cell differentiation

ABSTRACT: A miR-23~27~24 regulon that controls follicular helper T cell differentiation

PROVIDER: PRJNA486508 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7705780.fastq.gz	Fastqsanger.gz
	SRR7705790.fastq.gz	Fastqsanger.gz
	SRR7705800.fastq.gz	Fastqsanger.gz
	SRR7705781.fastq.gz	Fastqsanger.gz
	SRR7705791.fastq.gz	Fastqsanger.gz

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A miR-23~27~24 regulon that controls follicular helper T cell differentiation

Project description:Follicular helper T (Tfh) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged as important players in regulating Tfh cell biology. Here, we show that loss of miR-23~27~24 clusters in T cells resulted in elevated Tfh cell frequencies upon different immune challenges whereas overexpression of this miRNA family led to reduced Tfh cell responses. Mechanistically, miR-23~27~24 clusters coordinately control Tfh cells through targeting a network of genes that are crucial for Tfh cell biology. Among them, thymocyte selection-associated HMG-box protein (TOX) was identified as a central transcription regulator in Tfh cell development. TOX is highly up-regulated in both mouse and human Tfh cells in a BCL6-dependent manner. In turn, TOX promotes the expression of multiple molecules that play critical roles in Tfh cell differentiation and function. Collectively, our study on miR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in orchestrating Tfh cell responses.

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