Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Akkermansia muciniphila reduces lipid absorption through activating AMPK in the jejunum

ABSTRACT: Akkermansia muciniphila reduces lipid absorption through activating AMPK in the jejunum

PROVIDER: PRJNA1069053 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27731231_1.fastq.gz	Fastqsanger.gz
	SRR27731231_2.fastq.gz	Fastqsanger.gz
	SRR27731232_1.fastq.gz	Fastqsanger.gz
	SRR27731232_2.fastq.gz	Fastqsanger.gz
	SRR27731233_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Akkermansia muciniphila reduces lipid absorption through activating AMPK in the jejunum

Project description:Akkermansia muciniphila (Akk) associated with multiple metabolic diseases and administration of Akk can improve the metabolic disorders. However, little is known about the effect of Akk on jejunal epithelial cells which absorb lipid and interact with oral administrated Akk. We oral administrated Akk to mice and measured the lipid absorption and gene expression in small intestinal epithelial cells. The long-term effect of Akk treatment reduced lipid deposits in the liver and adipocytes with improved the glucose metabolism. This is particularly caused by reduced lipid absorption in jejunal epithelia. Akk feeding reduced the expression of those genes that regulate synthesis and cell cycles, characters of the host cell responding to energy deficiency. In fact, we detected increased AMPK-alpha phosphorylation levels in Akk-treated jejunal epithelial cells both in vivo and in vitro. Furthermore, activating AMPK inhibits lipids absorption in jejunum. Thus, we conclude that oral administration of Akk activates the AMPK pathway and represses the lipid absorption in jejunal epithelial cells, which contributes to the metabolic benefits of oral Akk administration.

2025-01-25 | GSE254234 | GEO

Akkermansia muciniphila outer membrane protein Amuc_0904 promotes goblet cell differentiation

Project description:Akkermansia muciniphila is recognized as a promising probiotic that improves the symptoms of a variety of diseases. However, the role and mechanism of A. muciniphila in regulating intestinal homeostasis remain to be explored. Here, we discovered that A. muciniphila was dramatically increased during colitis recovery, and its colonization greatly increased goblet cells to protect the intestinal barrier in mice. Amuc_0904, a previously uncharacterized A. muciniphila outer membrane protein, was identified to induce goblet cell differentiation.

2025-02-05 | GSE288821 | GEO

Akkermansia muciniphila

Project description:Akkermansia muciniphila overview

| PRJNA36235 | ENA

Akkermansia muciniphila proteome.

Project description:Akkermansia muciniphila, a common member of the human gut microbiota, is considered to be a beneficial resident of the intestinal mucus layer. Surface-exposed molecules produced by this organism likely play important roles in colonization and communication with other microbes and the host, but the protein composition of the outer membrane has not been characterized thus far. Herein we identify A. muciniphila proteins after enrichment and fractionation of the outer membrane proteome of A. muciniphila.

2016-09-27 | PXD004400 | Pride

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA921972 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA1145077 | ENA

Akkermansia muciniphila Membrane Protein Improves Cognitive Function in Aged Mice by Reducing IL-6 Expression

Project description:We implemented transcriptomic analyses of blood and hippocampus of old mice treated with Akkermansia muciniphila Membrane Protein for 8 weeks.

2023-08-25 | GSE162123 | GEO

Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

Project description:Total RNA from ileum of three groups of mice are sequenced. The three groups are 1. wild type mice. 2. mice with IFNg gene knockout. 3. IFNg gene knockout mice after colonization of Akkermansia muciniphila

2015-06-05 | E-MTAB-3633 | biostudies-arrayexpress

Akkermansia muciniphila

Project description:Akkermansia muciniphila Raw sequence reads

| PRJNA915585 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Raw sequence reads

| PRJNA758508 | ENA