Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Coccidioides posadasii

ABSTRACT: A dimorphic ascomycete causing coccidioidomycosis and morphologically indistinguishable from Coccidioides immitis.

PROVIDER: PRJNA10735 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR14825512.fastq.gz	Fastqsanger.gz
	SRR14825513.fastq.gz	Fastqsanger.gz
	SRR14825514.fastq.gz	Fastqsanger.gz
	SRR14825515.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 323

Similar Datasets

Proteogenomic Re-annotation of Coccidioides posadasii strain Silveira

Project description:The aims of this study were to present modifications to the annotations of the genome of C. posadasii, one of two closely related species of Coccidioides, a dimorphic fungal pathogen that causes coccidioidomycosis, also called Valley Fever. Proteins present in lysates and filtrates of in vitro grown mycelia and parasitic phase spherules from C. posadasii strain Silveira were analyzed using a GeLC-MS/MS method.

2017-11-08 | PXD006489 | Pride

Spatial Transcriptomics of Lungs Infected with Coccidioides posadasii

Project description:Coccidioidomycosis, or Valley Fever, is a lung disease caused by inhaling Coccidioides fungi, prevalent in the Southwestern U.S., Mexico, and parts of Central and South America. Climate change is contributing to the spread of this disease. Many cases are asymptomatic, some are often misdiagnosed, and a small subset can progress to severe illness. To better understand lung responses during late Coccidioides infection, we used 10x Visium spatial transcriptomics. We analyzed non-infected lung (D0) and infected lung at 14 days post-infection (D14).

2024-11-13 | GSE274767 | GEO

scRNA-seq time-course of Coccidioides posadasii infected lungs

Project description:Coccidioidomycosis, or Valley Fever, is a lung disease caused by inhaling Coccidioides fungi, prevalent in the Southwestern U.S., Mexico, and parts of Central and South America. Climate change is contributing to the spread of this disease. Many cases are asymptomatic, some are often misdiagnosed, and a small subset can progress to severe illness. To better understand lung responses during Coccidioides infection, we used single-cell RNA sequencing (scRNA-seq). We analyzed non-infected lungs (D0) and infected lungs at 5, 9, and 14 days post-infection (D5, D9, D14).

2024-11-13 | GSE274766 | GEO

Gene expression in human fungal pathogen Coccidioides immitis changes as mycelia differentiate into spherules and mature

2013-07-11 | GSE44225 | GEO

Gene expression in human fungal pathogen Coccidioides immitis changes as mycelia differentiate into spherules and mature

Project description:Coccidioides immitis (C. immitis) is a dimorphic fungus that causes disease in mammals including human beings. It grows as a mycelium in the soil but differentiates into a pathogenic structure called a spherule in the host. We compared the transcriptome of C. immitis mycelia and day 2 and day 8 spherules grown in vitro using a custom custom oligonucleotide microarray from Nimblegen. C. immitis RS strain isolated from infected mice was grown on agar. Arthroconidia was harvested and inoculated into mycelial spores. RNA was extracted from spores at different days post-inoculation and hybridized to a custom Nimblegen array, in order to identify differentially expressed genes between mycelia and spherules.

2013-07-11 | E-GEOD-44225 | biostudies-arrayexpress

Coccidioides posadasii

Project description:Coccidioides posadasii in Caribe

| PRJNA438145 | ENA

Coccidioides immitis

Project description:Pathogenic fungus that is morphologically indistinguishable from Coccidioides posadasii both cause the disease coccidioidomycosis

| PRJNA12821 | ENA

Coccidioides posadasii

Project description:Coccidioides posadasii Silveira long read assembly

| PRJNA664774 | ENA

Coccidioides posadasii

Project description:Coccidioides posadasii Transcriptome or Gene expression

| PRJNA169372 | ENA

AÂ Coccidioides posadasii CPS1Â deletion mutant is avirulent and protects mice from lethal infection

Project description:TheÂ CPS1Â gene was identified as a virulence factor in the maize pathogen, Cochliobolus heterostrophus. Hypothesizing that the homologous gene in Coccidioides posadasiiÂ (Cp) could be important for virulence, we created a deletion mutant,Â Îcps1, which was unable to cause disease in three strains of mice (C57BL/6, BALB/c, or the severely immunodeficient NOD-scid,Î³cnullÂ [NSG]). Only a single colony was recovered from one of 60 C57BL/6 mice following intranasal infections of up to 4400 spores. Following administration of very high doses (10,000 to 2.5 x 10^7Â spores) to NSG and BALB/c mice, spherules were observed in lung sections at time points from day 3 to day 10 post-infection, but nearly all appeared degraded with infrequent endosporulation. Although the role ofÂ CPS1Â in virulence is not understood, phenotypic alterations and transcription differences of at least 33 genes inÂ Îcps1Â vs. Cp is consistent with both metabolic and regulatory functions for the gene. The inÂ vitroÂ phenotype ofÂ Îcps1Â showed slower growth of mycelia with delayed and lower spore production compared to Cp, andÂ in vitro spherules were smaller. Vaccination of C57BL/6 or BALB/c mice with liveÂ Îcps1 spores either intranasally, intraperitoneally or subcutaneously resulted in over 95% survival with mean residual lung fungal burdens <1000 colony-forming units from an otherwise lethal Cp intranasal infection. Considering its apparently complete attenuation of virulence and the high degree of resistance to Cp infection when used as a vaccine,Â Îcps1Â is a promising vaccine candidate for preventing coccidioidomycosis in humans or other animals. Wild type and CPS1 deletion mutant strains of Coccidioides posadasii strain Silveira spherules grown for 48 hours in Converse medium at 38 degrees celsius in duplicate. RNAseq was performed on an Illumina HiSeq2000 (2x100 paired end).

2016-08-15 | E-GEOD-85364 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data