Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Clostridium sporogenes-derived metabolites protect against colonic inflammation

ABSTRACT: Clostridium sporogenes-derived metabolites protect against colonic inflammation

PROVIDER: PRJNA1100564 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28699911.fastq.gz	Fastqsanger.gz
	SRR28699912.fastq.gz	Fastqsanger.gz
	SRR28699913.fastq.gz	Fastqsanger.gz
	SRR28699914.fastq.gz	Fastqsanger.gz
	SRR28699915.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Clostridium sporogenes-derived metabolites protect against colonic inflammation

Project description:Purpose: Gut microbiota-derived metabolites play a pivotal role in the maintenance of local gut homeostasis and can even induce systemic effects via accumulation in the bloodstream. Here, we demonstrate that mono-colonization of germ-free (GF) mice with Clostridium sporogenes protects mice from inflamation and death induced by DSS colitis. Method: 8-12-week-old male mice (GF, SPF and GF colonized with C. sporogenes (CS)) were treated with 2.5% DSS in drinking water for 5 days and colon tissue was isolated on day 7. RNA was isolated from the colon tissue and RNA sequenzing was performed. Results: Mono-colonization of GF mice with Clostridium sporogenes protected the mice from DSS colitis induced death, while producing high amounts of indole-3-propionic acid (IPA), branched chain (BCFA) and short-chain (SCFA) fatty acids. In comparison to CS mice, SPF mice showed much higher levels of inflammatory related genes and a worse histological score. Conclusion: Histological stainings and the RNAseq both showed high levels of protection of C. sporogenes colonized mice in colitis, compared to SPF and GF animals. The data provide evidence for a therapeutic potential of C. sporogenes for IBD patients.

2024-10-15 | GSE264024 | GEO

Caminicella sporogenes

Project description:Caminicella sporogenes overview

| PRJNA974113 | ENA

Neuropilin-1 high monocytes protect against neonatal inflammation

Project description:Neuropilin-1 high monocytes protect against neonatal inflammation

| PRJNA1097663 | ENA

Periportal macrophages protect against commensal-driven liver inflammation

Project description:Periportal macrophages protect against commensal-driven liver inflammation

| PRJNA879436 | ENA

Clostridium sporogenes

Project description:Clostridium sporogenes Raw sequence reads

| PRJNA559963 | ENA

Comparative genomic hybridization of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes

Project description:Genomic DNA of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes was subjected to analysis by DNA microarray.

2008-12-31 | E-MEXP-1637 | biostudies-arrayexpress

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

Project description:Diminished colonic health is associated with various age-related pathologies. In this study, we applied an integrative approach to reveal potential interactions between determinants of colonic health in aging C57BL/6J mice. Analysis of gut microbiota composition revealed an enrichment of various potential pathobionts, including Desulfovibrio spp., and a decline of the health-promoting Akkermansia spp. and Lactobacillus spp. during aging. Intraluminal concentrations of various metabolites varied between ages and we found evidence for an increased gut permeability at higher age. Colonic gene expression analysis suggested that during the early phase of aging (between 6 and 12 months), expression of genes involved in epithelial-to-mesenchymal transition and (re)organization of the extracellular matrix were increased. Differential expression of these genes was strongly correlated with Bifidobacterium spp. During the later phase of aging (between 12 and 28 months), gene expression profiles pointed towards a diminished antimicrobial defense and were correlated with an uncultured Gastranaerophilales spp. This study demonstrates that aging is associated with pronounced changes in gut microbiota composition and colonic gene expression. Furthermore, the strong correlations between specific bacterial genera and host gene expression may imply that orchestrated interactions take place in the vicinity of the colonic wall and potentially mediate colonic health during aging.

2018-05-09 | GSE113257 | GEO

Clostridium sporogenes

Project description:Clostridium sporogenes Genome sequencing and assembly

| PRJNA355889 | ENA

Clostridium sporogenes

Project description:Clostridium sporogenes Genome sequencing and assembly

| PRJNA278445 | ENA

Commensal bacteria protect against food allergen sensitization

Project description:Analysis of colonic epithelial cell gene expression in germ-free, Bacteroides uniformis-colonized, and Clostridia-colonized gnotobiotic mice. Bacteria were isolated from our SPF mouse facility and were used to selectively colonize germ-free mice. Germ free mice were left germ free or were colonized with Bacteroides uniformis or a consortium of Clostridia. Total RNA was extraced from colonic epithelial cells.

2014-08-15 | E-GEOD-60039 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data