Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transciptional profiling of polyIC stimulated alveolar macrophages isolated from naive or SARS-CoV-2 recovered mice

ABSTRACT: Transciptional profiling of polyIC stimulated alveolar macrophages isolated from naive or SARS-CoV-2 recovered mice

PROVIDER: PRJNA1103796 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transciptional profiling of polyIC-treated or untreated, polyIC-experience or naive primary murine alveolar macrophages

Project description:Transciptional profiling of polyIC-treated or untreated, polyIC-experience or naive primary murine alveolar macrophages

| PRJNA1103797 | ENA

Transciptional profiling of polyIC stimulated alveolar macrophages isolated from naive or SARS-CoV-2 recovered mice

Project description:Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic potential and wide-ranging impact on global health. Here, we investigated epigenetic imprinting across cell lineages in a disease relevant murine model of SARS-CoV-2 recovery. Past SARS-CoV-2 infection resulted in increased chromatin accessibility of type I interferon (IFN-I) related transcription factors and transcriptionally poised antiviral genes in alveolar macrophages. Mechanistically, viral pattern recognition and canonical IFN-I signaling were required for establishment of this innate immune memory and resulting augmented secondary antiviral responses. SARS-CoV-2-associated innate immune memory in alveolar macrophages was necessary and sufficient to ameliorate secondary disease caused by the heterologous respiratory pathogen influenza A virus. Insights into how innate immune memory shapes outcome of heterologous secondary diseases could facilitate the development of broadly effective therapeutic strategies.

2024-10-02 | GSE264679 | GEO

Transciptional profiling of polyIC-treated or untreated, polyIC-experience or naive primary murine alveolar macrophages

Project description:Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic potential and wide-ranging impact on global health. Here, we investigated epigenetic imprinting across cell lineages in a disease relevant murine model of SARS-CoV-2 recovery. Past SARS-CoV-2 infection resulted in increased chromatin accessibility of type I interferon (IFN-I) related transcription factors and transcriptionally poised antiviral genes in airway-resident macrophages. Mechanistically, viral pattern recognition and canonical IFN-I signaling were required for establishment of this innate immune memory and resulting augmented secondary antiviral responses. SARS-CoV-2-associated innate immune memory in airway-resident macrophages was necessary and sufficient to ameliorate secondary disease caused by the heterologous respiratory pathogen influenza A virus. Insights into how innate immune memory shapes outcome of heterologous secondary diseases could facilitate the development of broadly effective therapeutic strategies.

2024-10-02 | GSE264683 | GEO

AmpliSeq Transcriptome Analysis of cells stimulated with polyIC in presence of GFP or NS5 protein

Project description:We compared polyIC stimulated cells in the presence of either GFP or NS5 protein

2018-08-18 | GSE118686 | GEO

Transciptional profiling of human mTEChi

Project description:Transciptional profiling of human mTEChi

| PRJNA736302 | ENA

Transcriptome sequencing wide functional analysis of human mesenchymal stem cells with PolyIC treatment

Project description:Using RNA-seq, we report here that BM-MSC cells have a distinct transcriptomic signature and express a unique cluster of transcripts in response to 4 hrs polyIC (10 ug/ml).

2019-04-03 | GSE109181 | GEO

Expression data from PolyIC treated EndoC-ßH1 cells

Project description:Expression data from PolyIC treated EndoC-ßH1 cells

| PRJNA412004 | ENA

Transcription profiling of mouse lung fibroblasts and Lewis lung cells to investigate the transciptional regulation that governs cell-cell fusion process

Project description:This study aimed to investigate the transciptional regulation that governs cell-cell fusion process.

2008-06-30 | E-TABM-381 | biostudies-arrayexpress

Transciptional profile of a M. smegmatis mc2155 ΔsigF strain under standard growth conditions

Project description:Comparing transciptional profile of a M. smegmatis mc2155 ΔsigF strain and wild type (control) in in vitro culture at two time points (exponential phase and stationary phase) for identification of SigF-dependent genes.

2010-03-31 | GSE19145 | GEO

AmpliSeq Transcriptome Analysis of cells stimulated with polyIC in presence of GFP or NS5 protein

Project description:AmpliSeq Transcriptome Analysis of cells stimulated with polyIC in presence of GFP or NS5 protein

| PRJNA486456 | ENA