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Project description:Strand-specific RNA-seq of nine rat tissues
2015-04-13 | E-MTAB-2800 | ExpressionAtlas
Project description:RNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
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Project description:RNA-seq of rat NSCs stimulated with lithium and/or photon radiation.
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Project description:RNA-seq of the whole retina of rat intravitreally injected with aldosterone
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Project description:Rat RNA-seq time-series of the development of seven major organs
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Project description:A rat RNA-Seq transcriptomic Bodymap across eleven organs and four developmental stages
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Project description:Transcription profiling of rat kidney samples from normal and acute hypotensive animals
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Project description:The rat sub-total nephrectomy (SNx) is a functional model of chronic kidney disease (CKD), where the main pathological driver is glomerular hypertension. Comprehensive transcriptomics and proteomics analyses on the rat SNx model were performed to identify biomarkers in plasma or urine that correlate with kidney disease and functional kidney loss. SWATH proteomics and bulk RNA-sequencing transcriptomics (RNA-seq), with SWATH also performed on plasma and urine. Differential expression analysis demonstrated significant dysregulation of genes and proteins involved in fibrosis, metabolism, and immune response in the SNx rats compared to controls. Gene ontology analysis of the intersecting genes and proteins from both studies demonstrated common biology between animal cohorts that reached the predefined kidney disease thresholds (serum creatinine >2-fold or proteinuria >3-fold increase over sham-operated). About a dozen significantly differential molecules were detected with consistent directional changes in both transcriptomics and proteomics datasets. These molecules were detected independently in kidney (both RNA and protein) and urine (protein only), but not in plasma. The bioinformatics analysis enabled the identification of mechanistic CKD biomarkers whose co-expression have previously been both implicated in fibrosis and detected in urine in CKD patients.
2025-04-25 | PXD048564 | Pride
Project description:RNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from lizard
2019-05-15 | E-MTAB-3727 | ExpressionAtlas
Project description:RNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from chicken
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