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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

ABSTRACT: Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

PROVIDER: PRJNA1137400 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29884700_1.fastq.gz	Fastqsanger.gz
	SRR29884700_2.fastq.gz	Fastqsanger.gz
	SRR29884701_1.fastq.gz	Fastqsanger.gz
	SRR29884701_2.fastq.gz	Fastqsanger.gz
	SRR29884698_1.fastq.gz	Fastqsanger.gz

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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

| PRJNA983290 | ENA

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

| PRJNA983297 | ENA

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

Project description:The list of circular RNAs (circRNAs) involved in tumor metabolic reprogramming is rapidly increasing, but whether circRNAs have a role in linking epigenetic modification with lipid metabolism remains elusive. Here, we demonstrate that the circRNA circEPB41(2), which expression is driven by HNRNPA1 in response to glucose deprivation, is important for de novo lipogenesis. Moreover, we uncovered a genome-wide decrease in specific histone acetylation after circEPB41(2) depletion. These changes are associated with altered gene expression and observed cellular phenotypes, suggesting their functional significance. Mechanistically, we showed that circEPB41(2) regulates histone acetylation in part by modulating the stability and polyadenylation of SIRT6 through binding and maintaining the demethylase activity of FTO. Accordingly, circEPB41(2) silencing inhibited cellular lipid accumulation, suppressed cell proliferation, and inhibited cancer xenograft growth. Thus, circEPB41(2) may consider a target for cancer treatment.

2024-07-25 | GSE272595 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

2023-10-11 | GSE234823 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

2023-10-11 | GSE234822 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-11 | GSE234825 | GEO

Dynamic changes in tRNA modifications and abundance during T-cell activation [ncRNA-seq]

Project description:Dynamic changes in tRNA modifications and abundance during T-cell activation [ncRNA-seq]

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Discovery of RUF6 ncRNA interacting proteins involved in P. falciparum immune evasion

Project description:RUF6 is a ncRNA gene family that is transcribed by RNA Polymerase III but actively regulates the Pol II-transcribed var virulence gene family. Understanding how RUF6 ncRNA connect to downstream effectors is lacking. We developed an RNA-directed proteomic discovery (ChIRP-MS) protocol to identify in vivo RUF6 ncRNA protein interactions. The RUF6 ncRNA interactome was purified with biotinylated antisense oligonucleotides. Quantitative label-free mass spectrometry identified several unique proteins linked to gene transcription including. Affinity purification of Pf-DDX5 identified proteins originally found by our RUF6-ChIRP protocol, validating the technique’s robustness for identifying ncRNA interactomes in P. falciparum. Our work identifies a RUF6 ncRNA protein complex that interacts with RNA Pol II to sustain var gene expression.

2022-11-15 | PXD036801 | Pride

FASN-dependent de novo lipogenesis is required for brain development

Project description:Fate and behaviour of neural progenitor cells is tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells, govern progenitor function. However, the role of de novo lipogenesis, which is the conversion of glucose into fatty acids through the multi-enzyme protein fatty acid synthase (FASN), for brain development remains unknown. Using Emx1Cre-mediated, tissue-specific deletion of Fasn in the mouse embryonic telencephalon, we show that loss of FASN causes severe microcephaly, largely due to altered polarity of apical, radial glia progenitors (APs) and reduced progenitor proliferation. Further, genetic deletion and pharmacological inhibition of FASN in human embryonic stem cell (ESC)-derived forebrain organoids identifies a conserved role of FASN-dependent lipogenesis for radial glia cell polarity and progenitor expansion in the developing human forebrain. Thus, our data establish a role of de novo lipogenesis for mouse and human brain development and identify a link between progenitor cell polarity and lipid metabolism.

2022-01-14 | PXD026110 | Pride

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